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    CG15117 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15117provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034417
    Locus tag
    Dmel_CG15117
    See related
    AllianceGenome:FB:FBgn0034417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG15117
    Summary
    Predicted to enable beta-glucuronidase activity and carbohydrate binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and extraembryonic structure. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15117 in Genome Data Viewer
    Location:
    56B5-56B5; 2-88 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19122231..19129300, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15009736..15016805, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1A Neighboring gene Ionotropic receptor 56a Neighboring gene brother of tout-velu Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuromuscular degeneration and locomotor deficit in a Drosophila model of mucopolysaccharidosis VII is attenuated by treatment with resveratrol. Bar S, et al. Dis Model Mech, 2018 Nov 20. PMID 30459155, Free PMC Article
    2. A sleep-promoting role for the Drosophila serotonin receptor 1A. Yuan Q, et al. Curr Biol, 2006 Jun 6. PMID 16753559
    3. Genetic and behavioral analysis of natural variation in Drosophila melanogaster pupation position. Riedl CA, et al. Fly (Austin), 2007 Jan-Feb. PMID 18690058
    4. MidExDB: a database of Drosophila CNS midline cell gene expression. Wheeler SR, et al. BMC Dev Biol, 2009 Nov 10. PMID 19903351, Free PMC Article
    5. Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. Webb JL, et al. PLoS One, 2021. PMID 34379632, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-glucuronidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-glucuronidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15117-PA
    CG15117-PB
    CG15117-PC
    CG15117-PD
    CG15117-PE
    CG15117-PF
    NP_001014535.1
    NP_001286599.1
    NP_001286600.1
    NP_001286601.1
    NP_611395.1
    NP_725851.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19122231..19129300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137551.3 → NP_611395.1  uncharacterized protein Dmel_CG15117, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV29, Q7K173
      Related
      FBpp0085777
      Conserved Domains (4) summary
      PRK10150
      Location:34 → 634
      PRK10150; beta-D-glucuronidase; Provisional
      pfam00703
      Location:224 → 334
      Glyco_hydro_2; Glycosyl hydrolases family 2
      pfam02837
      Location:43 → 222
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
      cl23725
      Location:342 → 631
      Glyco_hydro_1; Glycosyl hydrolase family 1

    2. NM_166324.2 → NP_725851.1  uncharacterized protein Dmel_CG15117, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBG9, Q6NL66
      Related
      FBpp0085778
      Conserved Domains (4) summary
      PRK10150
      Location:48 → 648
      PRK10150; beta-D-glucuronidase; Provisional
      pfam00703
      Location:238 → 348
      Glyco_hydro_2; Glycosyl hydrolases family 2
      pfam02837
      Location:57 → 236
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
      cl23725
      Location:356 → 645
      Glyco_hydro_1; Glycosyl hydrolase family 1

    3. NM_001014535.2 → NP_001014535.1  uncharacterized protein Dmel_CG15117, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBH0, C8VV29
      Conserved Domains (4) summary
      PRK10150
      Location:34 → 634
      PRK10150; beta-D-glucuronidase; Provisional
      pfam00703
      Location:224 → 334
      Glyco_hydro_2; Glycosyl hydrolases family 2
      pfam02837
      Location:43 → 222
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
      cl23725
      Location:342 → 631
      Glyco_hydro_1; Glycosyl hydrolase family 1

    4. NM_001299670.1 → NP_001286599.1  uncharacterized protein Dmel_CG15117, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGY4, C8VV29
      Conserved Domains (4) summary
      PRK10150
      Location:26 → 626
      PRK10150; beta-D-glucuronidase; Provisional
      pfam00703
      Location:216 → 326
      Glyco_hydro_2; Glycosyl hydrolases family 2
      pfam02837
      Location:35 → 214
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
      cl23725
      Location:334 → 623
      Glyco_hydro_1; Glycosyl hydrolase family 1

    5. NM_001299672.1 → NP_001286601.1  uncharacterized protein Dmel_CG15117, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFU6, C8VV29
      Conserved Domains (1) summary
      PRK10150
      Location:1 → 601
      PRK10150; beta-D-glucuronidase; Provisional

    6. NM_001299671.1 → NP_001286600.1  uncharacterized protein Dmel_CG15117, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFU6, C8VV29
      Conserved Domains (1) summary
      PRK10150
      Location:1 → 601
      PRK10150; beta-D-glucuronidase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFU6 A0A0B4LFU6
    A0A0B4LGY4 A0A0B4LGY4
    A1ZBG9 A1ZBG9
    A1ZBH0 A1ZBH0
    Q7K173 Q7K173

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