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    osp outspread [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ospprovided by FlyBase
    Official Full Name
    outspreadprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003016
    Locus tag
    Dmel_CG3479
    See related
    AllianceGenome:FB:FBgn0003016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alw; anon-WO02059370.75; BG:DS01486.5; BG:DS01486.7; BG:DS07721.2; CG3479; Dmel\CG3479; l(2)rJ571; v(2)rJ571
    Summary
    Predicted to enable actin filament binding activity. Predicted to be active in actin cytoskeleton. Is expressed in embryonic foregut; embryonic hypopharynx; gland; salivary gland body primordium; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 28. Orthologous to several human genes including MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See osp in Genome Data Viewer
    Location:
    35B3-35B4; 2-50 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14599196..14689340, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14599196..14689340, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Proline-AGG 1-2 Neighboring gene transfer RNA:Proline-AGG 1-3 Neighboring gene transfer RNA:Proline-AGG 1-4 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43411 Neighboring gene Adh-related Neighboring gene Alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster. Loehlin DW, et al. G3 (Bethesda), 2023 Sep 30. PMID 37462278, Free PMC Article
    2. FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster. Moschetti R, et al. Mol Genet Genomics, 2004 May. PMID 15060822
    3. The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. McNabb S, et al. Genetics, 1996 Jun. PMID 8725237, Free PMC Article
    4. Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster. Fossett NG, et al. Mutat Res, 1990 Jul. PMID 2114535
    5. Molecular analysis of the Adh region of the genome of Drosophila melanogaster. Chia W, et al. J Mol Biol, 1985 Dec 20. PMID 3005593

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c14619298-14618937 mobile_element_type = transposon:jockey{}370
    • Loc: c14651730-14642626 mobile_element_type = transposon:roo{}371

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    outspread
    Names
    CG3479-PC
    CG3479-PD
    CG3479-PE
    CG3479-PF
    arc-like wing
    arclike wing
    osp-PC
    osp-PD
    osp-PE
    osp-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14599196..14689340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169504.2 → NP_001162975.1  outspread, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEG2, A9UN92, B7YZW1, E1JHH8, Q24231, Q27421, Q7KT89, Q8MSX4, Q9VJS4
      Conserved Domains (4) summary
      COG0419
      Location:726 → 1353
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01236
      Location:48 → 191
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:509 → 613
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:509 → 603
      PH; PH domain

    2. NM_078843.6 → NP_523567.5  outspread, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523567.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27421
      Conserved Domains (4) summary
      COG0419
      Location:717 → 1344
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01236
      Location:48 → 182
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:500 → 604
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:500 → 594
      PH; PH domain

    3. NM_165089.4 → NP_723879.3  outspread, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723879.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27421
      Conserved Domains (4) summary
      COG0419
      Location:717 → 1344
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01236
      Location:48 → 182
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:500 → 604
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:500 → 594
      PH; PH domain

    4. NM_001144354.3 → NP_001137826.1  outspread, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137826.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27421
      Conserved Domains (4) summary
      COG0419
      Location:726 → 1353
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01236
      Location:48 → 191
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:509 → 613
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:509 → 603
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27421.5 Q27421

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