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    PUT7 Put7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850988, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PUT7
    Official Full Name
    Put7p
    Primary source
    SGD:S000004273
    Locus tag
    YLR283W
    See related
    AllianceGenome:SGD:S000004273; FungiDB:YLR283W; VEuPathDB:YLR283W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in regulation of proline metabolic process. Located in endoplasmic reticulum and mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PUT7 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (705186..706130)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rso55p Neighboring gene dodecenoyl-CoA isomerase Neighboring gene S-adenosylmethionine-dependent methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. Zulkifli M, et al. Nat Commun, 2020 Sep 25. PMID 32978391, Free PMC Article
    2. Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. Nguyen HD, et al. PLoS One, 2013. PMID 23824283, Free PMC Article
    3. Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker. Makepeace KAT, et al. Mol Cell Proteomics, 2020 Apr. PMID 32051233, Free PMC Article
    4. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
    5. Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis. Corcoles-Saez I, et al. Dev Cell, 2018 Aug 20. PMID 30130531

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of proline metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Put7p
    NP_013385.1
    • Regulator of mitochondrial proline metabolism; tethered with Fmp32p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      705186..706130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182170.1 → NP_013385.1  TPA: Put7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013385.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYS7, Q05867
      UniProtKB/TrEMBL
      A7A1G4, C7GVT0
      Conserved Domains (1) summary
      pfam07798
      Location:103 → 270
      DUF1640; Protein of unknown function (DUF1640)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05867.1

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