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    tif471 translation initiation factor eIF4G [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542290, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tif471
    Official Full Name
    translation initiation factor eIF4G
    Primary source
    PomBase:SPAC17C9.03
    Locus tag
    SPOM_SPAC17C9.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tif471 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4491952..4496578, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene sorting and assembly machinery complex subunit Sam50 Neighboring gene mediator complex subunit Med27 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene alpha-aminoadipate reductase phosphopantetheinyl transferase Lys7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules. Hashemzadeh-Bonehi L, et al. Genes Cells, 2003 Feb. PMID 12581158
    2. Cellular stress induces cytoplasmic RNA granules in fission yeast. Nilsson D, et al. RNA, 2011 Jan. PMID 21098141, Free PMC Article
    3. Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks. Selvanathan SP, et al. J Biol Chem, 2010 May 7. PMID 20231270, Free PMC Article
    4. Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress. Cabrera M, et al. Cell Rep, 2020 Feb 18. PMID 32075773
    5. Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies. Hsiao WY, et al. Mol Cell Biol, 2020 Apr 13. PMID 32071154, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF4G

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4491952..4496578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020030.3 → NP_594602.1  translation initiation factor eIF4G [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594602.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78832, Q10475
      Conserved Domains (5) summary
      pfam05568
      Location:213 → 284
      ASFV_J13L; African swine fever virus J13L protein
      TIGR02794
      Location:470 → 574
      tolA_full; TolA protein
      pfam01346
      Location:515 → 564
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
      pfam02854
      Location:1009 → 1244
      MIF4G; MIF4G domain
      pfam12152
      Location:784 → 846
      eIF_4G1; Eukaryotic translation initiation factor 4G1
    Nucleotide Protein
    Heading Accession and Version

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