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    Wdr62 WD repeat domain 62 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33367, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr62provided by FlyBase
    Official Full Name
    WD repeat domain 62provided by FlyBase
    Primary source
    FLYBASE:FBgn0031374
    Locus tag
    Dmel_CG7337
    See related
    AllianceGenome:FB:FBgn0031374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7337; Dmel\CG7337; Q0E8U7_DROME; wdr62; WDR62
    Summary
    Involved in regulation of mitotic cell cycle. Located in interphase microtubule organizing center and mitotic spindle. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal epidermis primordium; embryonic foregut; and epithelium. Used to study high grade glioma; microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Human ortholog(s) of this gene implicated in intellectual disability; nephronophthisis 20; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62) and MAPKBP1 (mitogen-activated protein kinase binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Wdr62 in Genome Data Viewer
    Location:
    22B4-22B6; 2-3 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1884622..1944289)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1884622..1944289)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44075 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glycine-GCC 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in interphase microtubule organizing center PubMed 
    is_active_in mitotic spindle  
    located_in mitotic spindle PubMed 
    located_in spindle pole  

    General protein information

    Preferred Names
    WD repeat domain 62
    Names
    CG7337-PA
    CG7337-PB
    CG7337-PC
    CG7337-PD
    CG7337-PE
    CG7337-PF
    CG7337-PG
    CG7337-PH
    Wdr62-PA
    Wdr62-PB
    Wdr62-PC
    Wdr62-PD
    Wdr62-PE
    Wdr62-PF
    Wdr62-PG
    Wdr62-PH

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1884622..1944289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134786.6 → NP_608630.2  WD repeat domain 62, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608630.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ54
      Related
      FBpp0077488
      Conserved Domains (3) summary
      COG2319
      Location:402 → 716
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:514 → 555
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:405 → 717
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001103581.3 → NP_001097051.1  WD repeat domain 62, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ54
      Conserved Domains (3) summary
      COG2319
      Location:402 → 716
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:514 → 555
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:405 → 717
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001272958.1 → NP_001259887.1  WD repeat domain 62, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBP2
      Conserved Domains (3) summary
      COG2319
      Location:402 → 716
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:514 → 555
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:405 → 717
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001103580.2 → NP_001097050.1  WD repeat domain 62, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT1
      Conserved Domains (3) summary
      COG2319
      Location:433 → 747
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:545 → 586
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:436 → 748
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. NM_001272957.1 → NP_001259886.1  WD repeat domain 62, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB01
      Conserved Domains (3) summary
      COG2319
      Location:385 → 747
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:505 → 540
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:436 → 748
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. NM_001258915.2 → NP_001245844.1  WD repeat domain 62, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE65
      Conserved Domains (3) summary
      COG2319
      Location:433 → 747
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:545 → 586
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:436 → 748
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. NM_001042862.2 → NP_001036327.1  WD repeat domain 62, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8U7
      Conserved Domains (3) summary
      COG2319
      Location:350 → 712
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:470 → 505
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:401 → 713
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. NM_001042863.2 → NP_001036328.1  WD repeat domain 62, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8U6
      Conserved Domains (3) summary
      COG2319
      Location:398 → 712
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:510 → 551
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:401 → 713
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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