Tep1 telomerase associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tep1provided by RGD
Official Full Name: telomerase associated protein 1provided by RGD
Primary source: RGD:3869
See related: EnsemblRapid:ENSRNOG00000051706 AllianceGenome:RGD:3869
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tlp1
Summary: Contributes to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Part of telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and stomach cancer. Orthologous to human TEP1 (telomerase associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 197.3), Heart (RPKM 107.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 56

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26519429..26567073, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24045876..24093526, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (27751186..27798839, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA binding	IEA Inferred from Electronic Annotation more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info
contributes_to telomerase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to telomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables telomerase activity	IEA Inferred from Electronic Annotation more info
contributes_to telomerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA-templated DNA biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in RNA-templated DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via recombination	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of telomerase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of telomerase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of telomerase holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: telomerase protein component 1

Names: p230; p240; p80 telomerase homolog; rTLP1; telomerase protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022591.2 → NP_072113.1 telomerase protein component 1

See identical proteins and their annotated locations for NP_072113.1

Status: PROVISIONAL

Source sequence(s)

U89282

UniProtKB/Swiss-Prot

O08653

UniProtKB/TrEMBL

A6KEB2, F1LPX8

Related

ENSRNOP00000073225.1, ENSRNOT00000079506.3

Conserved Domains (8) summary

COG2319
Location:1764 → 2201

WD40; WD40 repeat [General function prediction only]

cd00200
Location:1983 → 2276

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05386
Location:91 → 119

TEP1_N; TEP1 N-terminal domain

pfam05729
Location:1175 → 1350

NACHT; NACHT domain

pfam05731
Location:234 → 689

TROVE; TROVE domain

pfam13271
Location:921 → 1021

DUF4062; Domain of unknown function (DUF4062)

sd00039
Location:2076 → 2113

7WD40; WD40 repeat [structural motif]

cl02567
Location:1691 → 1966

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

26519429..26567073 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093640.2 → XP_038949568.1 telomerase protein component 1 isoform X1

Conserved Domains (5) summary

cd00200
Location:1129 → 1422

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:1222 → 1259

7WD40; WD40 repeat [structural motif]

pfam05729
Location:321 → 496

NACHT; NACHT domain

pfam13271
Location:59 → 167

DUF4062; Domain of unknown function (DUF4062)

cl29593
Location:837 → 1112

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039093642.1 → XP_038949570.1 telomerase protein component 1 isoform X3

Conserved Domains (3) summary

cd00200
Location:670 → 963

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:763 → 800

7WD40; WD40 repeat [structural motif]

cl29593
Location:378 → 653

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039093641.2 → XP_038949569.1 telomerase protein component 1 isoform X2

UniProtKB/TrEMBL

A6KEB3

Conserved Domains (4) summary

pfam05386
Location:91 → 119

TEP1_N; TEP1 N-terminal domain

pfam05729
Location:1175 → 1350

NACHT; NACHT domain

pfam05731
Location:234 → 689

TROVE; TROVE domain

pfam13271
Location:913 → 1021

DUF4062; Domain of unknown function (DUF4062)