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    MVB12 ubiquitin-binding ESCRT-I subunit protein MVB12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MVB12
    Official Full Name
    ubiquitin-binding ESCRT-I subunit protein MVB12
    Primary source
    SGD:S000003438
    Locus tag
    YGR206W
    See related
    AllianceGenome:SGD:S000003438; FungiDB:YGR206W; VEuPathDB:YGR206W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin binding activity. Involved in ATP export; negative regulation of protein-containing complex assembly; and protein targeting to vacuole. Located in cytosol and endosome. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MVB12 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (910432..910737)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative ATP-dependent kinase Neighboring gene Cir1p Neighboring gene phosphoserine phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Curtiss M, et al. Mol Biol Cell, 2007 Feb. PMID 17135292, Free PMC Article
    2. New component of ESCRT-I regulates endosomal sorting complex assembly. Chu T, et al. J Cell Biol, 2006 Dec 4. PMID 17145965, Free PMC Article
    3. ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting. Shields SB, et al. J Cell Biol, 2009 Apr 20. PMID 19380877, Free PMC Article
    4. Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Kostelansky MS, et al. Cell, 2007 May 4. PMID 17442384, Free PMC Article
    5. Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway. Oestreich AJ, et al. Mol Biol Cell, 2007 Feb. PMID 17151358, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mvb12 may function in regulating the interactions of ESCRT-I with cargo and other proteins of the ESCRT machinery to efficiently coordinate cargo sorting and release of ESCRT-I from the multivesicular body vesicles.
      Title: Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12.
    2. These data support a model in which Mvb12 impacts the selection of multivesicular body cargoes by modulating the cargo recognition capabilities of ESCRT-I.
      Title: Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway.
    3. Mvb12 stabilizes ESCRT-I in an oligomeric, inactive state in the cytosol to ensure that the ordered recruitment and assembly of ESCRT-I and -II is spatially and temporally restricted to the surface of the endosome after activation of the MVB reaction.
      Title: New component of ESCRT-I regulates endosomal sorting complex assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome transport via multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome HDA PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-binding ESCRT-I subunit protein MVB12
    NP_011722.3
    • ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      910432..910737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181335.3 → NP_011722.3  TPA: ubiquitin-binding ESCRT-I subunit protein MVB12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011722.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUY9, P42939
      UniProtKB/TrEMBL
      A6ZUL7, B3LI30, C7GRN9, C8Z999, G2WET5, N1P2J3
      Conserved Domains (1) summary
      pfam09452
      Location:9 → 98
      Mvb12; ESCRT-I subunit Mvb12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42939.1

    Gene LinkOut

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