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    hrpa-1 Heterogeneous nuclear ribonucleoprotein A1 [ Caenorhabditis elegans ]

    Gene ID: 177101, updated on 9-Dec-2024

    Summary

    Official Symbol
    hrpa-1
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein A1
    Primary source
    WormBase:WBGene00001999
    Locus tag
    CELE_F42A6.7
    See related
    AllianceGenome:WB:WBGene00001999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Involved in hemidesmosome assembly. Located in chromosome, telomeric region. Is expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with Paget disease of bone and frontotemporal dementia (multiple); and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) and HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hrpa-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (3336920..3338863, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein Neighboring gene pseudo Neighboring gene Uncharacterized protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding PubMed 
    enables mRNA 3'-UTR binding  
    enables nucleic acid binding  
    Process Evidence Code Pubs
    involved_in hemidesmosome assembly PubMed 
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome  
    located_in chromosome  
    located_in chromosome, telomeric region PubMed 
    located_in chromosome, telomeric region  
    located_in nucleus  
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    Heterogeneous nuclear ribonucleoprotein A1
    NP_001040945.1
    • Confirmed by transcript evidence
    NP_001367846.1
    • Partially confirmed by transcript evidence
    NP_001370723.1
    • Confirmed by transcript evidence
    NP_001379954.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3336920..3338863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380140.2 → NP_001367846.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd12328
      Location:77 → 149
      RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:1 → 63
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001392280.1 → NP_001379954.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd12328
      Location:77 → 149
      RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:1 → 63
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001383064.2 → NP_001370723.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22037, Q336L3, Q336L4, Q95X69
      Conserved Domains (2) summary
      cd12328
      Location:115 → 187
      RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:24 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. NM_001047480.6 → NP_001040945.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22037
      Conserved Domains (2) summary
      cd12328
      Location:115 → 187
      RRM2_hnRNPA_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A subfamily
      cd12578
      Location:24 → 101
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
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