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    Zfand2b zinc finger AN1-type containing 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363253, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfand2bprovided by RGD
    Official Full Name
    zinc finger AN1-type containing 2Bprovided by RGD
    Primary source
    RGD:1306260
    See related
    EnsemblRapid:ENSRNOG00000018639 AllianceGenome:RGD:1306260
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306260
    Summary
    Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein targeting to ER; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within SRP-dependent cotranslational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of proteasome complex. Predicted to be active in endoplasmic reticulum. Orthologous to human ZFAND2B (zinc finger AN1-type containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 74.1), Thymus (RPKM 72.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfand2b in Genome Data Viewer
    Location:
    9q33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84114170..84117115)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76665466..76668447)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82370887..82373843)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene reticulophagy regulator family member 2 Neighboring gene ATP binding cassette subfamily B member 6 Neighboring gene autophagy related 9A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains. Rahighi S, et al. Structure, 2016 Mar 1. PMID 26876100, Free PMC Article
    2. Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. Glinka T, et al. Biochem J, 2014 Jan 15. PMID 24160817
    3. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Yun C, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18467495, Free PMC Article
    4. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Osorio FG, et al. Nat Med, 2016 Jan. PMID 26692333
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116391

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 2B
    Names
    AIRAP-like protein
    arsenite-inducible RNA-associated protein-like protein
    zinc finger, AN1 type domain 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025745.1 → NP_001020916.1  AN1-type zinc finger protein 2B

      See identical proteins and their annotated locations for NP_001020916.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099215
      UniProtKB/Swiss-Prot
      Q4KLG9
      UniProtKB/TrEMBL
      A6JVY1, A6JVY4
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:198 → 213
      UIM; Ubiquitin interaction motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84114170..84117115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083879.2 → XP_038939807.1  AN1-type zinc finger protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q4KLG9
      UniProtKB/TrEMBL
      A6JVY1, A6JVY4
      Related
      ENSRNOP00000025219.6, ENSRNOT00000025219.7
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:198 → 213
      UIM; Ubiquitin interaction motif

    2. XM_006245245.5 → XP_006245307.1  AN1-type zinc finger protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006245307.1

      UniProtKB/TrEMBL
      A6JVY4
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:198 → 213
      UIM; Ubiquitin interaction motif

    3. XM_039083878.2 → XP_038939806.1  AN1-type zinc finger protein 2B isoform X1

      UniProtKB/TrEMBL
      A6JVY4
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:198 → 213
      UIM; Ubiquitin interaction motif

    4. XM_063267396.1 → XP_063123466.1  AN1-type zinc finger protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q4KLG9
      UniProtKB/TrEMBL
      A6JVY1

    5. XM_006245246.5 → XP_006245308.1  AN1-type zinc finger protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006245308.1

      UniProtKB/TrEMBL
      A6JVY4
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:198 → 213
      UIM; Ubiquitin interaction motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLG9.1 GenPept UniProtKB/Swiss-Prot:Q4KLG9

    Gene LinkOut

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