Zfp335 zinc finger protein 335 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp335provided by MGI
Official Full Name: zinc finger protein 335provided by MGI
Primary source: MGI:MGI:2682313
See related: Ensembl:ENSMUSG00000039834 AllianceGenome:MGI:2682313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nif1; NIF-1; Znf335; 1810045J01Rik
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone methyltransferase binding activity. Involved in brain development; neuron projection morphogenesis; and positive regulation of neuroblast proliferation. Acts upstream of or within several processes, including brain development; in utero embryonic development; and regulation of neurogenesis. Located in nucleus. Part of histone methyltransferase complex. Is expressed in brain and future brain. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 31.4), spleen adult (RPKM 20.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.27 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164733802..164756034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164891882..164912585, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression.
Title: The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression.
Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.
Title: Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.
The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.
Title: The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.
p35 interacts with NIF-1 and regulates the subcellular localization of the protein independent of Cdk5-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5
Title: p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).
Results suggest that NIF-1 directs neuronal morphogenesis during early developmental stages through modulating activity-dependent gene transcription
Title: NRC-interacting factor directs neurite outgrowth in an activity-dependent manner.
Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment.
Title: Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.
Znf335 null mice are embryonically lethal, and conditional knockout leads to severely reduced cortical size.
Title: Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Gene trapped (2)
Targeted (3) 1 citation
Transgenic (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebral cortex neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 335

Names: NRC-interacting factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199027.2 → NP_950192.2 zinc finger protein 335

See identical proteins and their annotated locations for NP_950192.2

Status: VALIDATED

Source sequence(s)

BC062921, CN721033

Consensus CDS

CCDS38331.1

UniProtKB/Swiss-Prot

A2A5K6, B2RXR9, Q3TZT1

Related

ENSMUSP00000038298.8, ENSMUST00000041361.14

Conserved Domains (4) summary

COG5189
Location:1026 → 1126

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:1049 → 1069

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1089 → 1114

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:1075 → 1099

zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

164733802..164756034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251805.2 → XP_030107665.1 zinc finger protein 335 isoform X1

Conserved Domains (4) summary

COG5189
Location:1027 → 1127

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:1050 → 1070

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1090 → 1115

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:1076 → 1100

zf-H2C2_5; C2H2-type zinc-finger domain
XM_030251807.2 → XP_030107667.1 zinc finger protein 335 isoform X2

UniProtKB/Swiss-Prot

A2A5K6, B2RXR9, Q3TZT1

Conserved Domains (4) summary

COG5189
Location:1026 → 1126

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:1049 → 1069

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1089 → 1114

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:1075 → 1099

zf-H2C2_5; C2H2-type zinc-finger domain
XM_030251806.2 → XP_030107666.1 zinc finger protein 335 isoform X1

Conserved Domains (4) summary

COG5189
Location:1027 → 1127

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:1050 → 1070

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1090 → 1115

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:1076 → 1100

zf-H2C2_5; C2H2-type zinc-finger domain
XM_036162334.1 → XP_036018227.1 zinc finger protein 335 isoform X2

UniProtKB/Swiss-Prot

A2A5K6, B2RXR9, Q3TZT1

Conserved Domains (4) summary

COG5189
Location:1026 → 1126

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:1049 → 1069

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1089 → 1114

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:1075 → 1099

zf-H2C2_5; C2H2-type zinc-finger domain