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    Tenm2 teneurin transmembrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 23964, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tenm2provided by MGI
    Official Full Name
    teneurin transmembrane protein 2provided by MGI
    Primary source
    MGI:MGI:1345184
    See related
    Ensembl:ENSMUSG00000049336 AllianceGenome:MGI:1345184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Odz2; Odz3; Ten-2; Ten-m2
    Summary
    Enables protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of filopodium assembly; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic membrane. Predicted to be active in glutamatergic synapse and neuron projection. Predicted to be extrinsic component of postsynaptic membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human TENM2 (teneurin transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.0), whole brain E14.5 (RPKM 2.9) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tenm2 in Genome Data Viewer
    Location:
    11 A4- A5; 11 21.96 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35897483..37881486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (36006656..37237053, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9361 Neighboring gene STARR-positive B cell enhancer ABC_E6965 Neighboring gene STARR-seq mESC enhancer starr_29194 Neighboring gene STARR-seq mESC enhancer starr_29197 Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene WW, C2 and coiled-coil domain containing 1 Neighboring gene predicted gene, 42072 Neighboring gene STARR-seq mESC enhancer starr_29200 Neighboring gene predicted gene 12126 Neighboring gene predicted gene, 42071 Neighboring gene predicted gene, 46251 Neighboring gene predicted gene, 33585 Neighboring gene STARR-seq mESC enhancer starr_29205 Neighboring gene STARR-seq mESC enhancer starr_29206 Neighboring gene predicted gene, 51889 Neighboring gene predicted gene, 22127 Neighboring gene predicted gene, 53696 Neighboring gene predicted gene, 51890 Neighboring gene STARR-seq mESC enhancer starr_29209 Neighboring gene predicted gene, 53695 Neighboring gene STARR-seq mESC enhancer starr_29211 Neighboring gene predicted gene, 33791 Neighboring gene predicted gene 12128 Neighboring gene STARR-seq mESC enhancer starr_29212 Neighboring gene STARR-seq mESC enhancer starr_29213 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 12130

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • mKIAA1127, D3Bwg1534e, 2610040L17Rik, 9330187F13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    teneurin-2
    Names
    odd Oz/ten-m homolog 2
    protein Odd Oz/ten-m homolog 2
    tenascin-M2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290702.1NP_001277631.1  teneurin-2 isoform 2

      See identical proteins and their annotated locations for NP_001277631.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AL645912, AL713915, AL713919, AL713956, BX000433, BX539311
      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      B9EJ72
      Conserved Domains (8) summary
      COG3209
      Location:16482441
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11991238
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23502427
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:539561
      EGF_2; EGF-like domain
      cl18310
      Location:11991529
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:626744
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26492726
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    2. NM_011856.4NP_035986.3  teneurin-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL645912, AL713915, AL713919, AL713956, BX000433, BX539311
      Consensus CDS
      CCDS24546.1
      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      A0A0A0MQB7
      Related
      ENSMUSP00000129951.2, ENSMUST00000163524.8
      Conserved Domains (10) summary
      COG3209
      Location:16792472
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:671700
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12301269
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23812458
      Rhs_assc_core; RHS repeat-associated core domain
      pfam05593
      Location:16721710
      RHS_repeat; RHS Repeat
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:580602
      EGF_2; EGF-like domain
      pfam15636
      Location:26822757
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12301560
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:725764
      DSL; Delta serrate ligand

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      35897483..37881486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156687.1XP_036012580.1  teneurin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:16892482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23912468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12401570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26902767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570885
      exchanger_TraA; outer membrane exchange protein TraA
    2. XM_006533290.4XP_006533353.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533353.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:16892482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23912468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12401570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26902767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570885
      exchanger_TraA; outer membrane exchange protein TraA
    3. XM_030245994.1XP_030101854.1  teneurin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:16892482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23912468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12401570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26902767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570885
      exchanger_TraA; outer membrane exchange protein TraA
    4. XM_036156689.1XP_036012582.1  teneurin-2 isoform X10

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:15782371
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11291168
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:22802357
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11291459
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10304
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:25792656
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:459774
      exchanger_TraA; outer membrane exchange protein TraA
    5. XM_036156690.1XP_036012583.1  teneurin-2 isoform X11

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:15482341
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10991138
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:22502327
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:10991429
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10304
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:25492626
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:702732
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:500738
      exchanger_TraA; outer membrane exchange protein TraA
    6. XM_006533295.4XP_006533358.1  teneurin-2 isoform X7

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:16192412
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11701209
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23212398
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:510532
      EGF_2; EGF-like domain
      cl18310
      Location:11701500
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:597715
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10304
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26202697
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    7. XM_011249009.3XP_011247311.1  teneurin-2 isoform X6

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:16412434
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11991227
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23432420
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:539561
      EGF_2; EGF-like domain
      cl18310
      Location:11991522
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:626744
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26422719
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    8. XM_006533287.4XP_006533350.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533350.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:16892482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23912468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12401570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26902767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570885
      exchanger_TraA; outer membrane exchange protein TraA
    9. XM_006533288.4XP_006533351.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533351.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:16892482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23912468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12401570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26902767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570885
      exchanger_TraA; outer membrane exchange protein TraA
    10. XM_030245995.2XP_030101855.1  teneurin-2 isoform X9

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (10) summary
      COG3209
      Location:16112404
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:671700
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:11691197
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23132390
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:576602
      EGF_2; EGF-like domain
      cl18310
      Location:11691492
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667803
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26122689
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam18372
      Location:611628
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
    11. XM_006533296.5XP_006533359.1  teneurin-2 isoform X8

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (10) summary
      COG3209
      Location:16182411
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:671700
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:11691208
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23202397
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:576602
      EGF_2; EGF-like domain
      cl18310
      Location:11691499
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667803
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26192696
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam18372
      Location:611628
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
    12. XM_006533293.5XP_006533356.1  teneurin-2 isoform X4

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (9) summary
      COG3209
      Location:16732466
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:798831
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12311259
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23752452
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:580602
      EGF_2; EGF-like domain
      cl18310
      Location:12311554
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667785
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26742751
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    13. XM_006533292.5XP_006533355.1  teneurin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      A0A0A0MQ92
      Related
      ENSMUSP00000052014.6, ENSMUST00000057207.6
      Conserved Domains (9) summary
      COG3209
      Location:16802473
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:798831
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12311270
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23822459
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:580602
      EGF_2; EGF-like domain
      cl18310
      Location:12311561
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667785
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26812758
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    14. XM_006533291.5XP_006533354.1  teneurin-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:16822475
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401268
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23842461
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:580602
      EGF_2; EGF-like domain
      cl18310
      Location:12401563
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667785
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26832760
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    15. XM_006533289.2XP_006533352.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533352.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:16892482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23912468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12401570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26902767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570885
      exchanger_TraA; outer membrane exchange protein TraA
    16. XM_036156688.1XP_036012581.1  teneurin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:16892482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12401279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23912468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12401570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26902767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570885
      exchanger_TraA; outer membrane exchange protein TraA
    17. XM_036156696.1XP_036012589.1  teneurin-2 isoform X21

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:14262219
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:9771016
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21282205
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:9771307
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:14152
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24272504
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:307622
      exchanger_TraA; outer membrane exchange protein TraA
    18. XM_036156698.1XP_036012591.1  teneurin-2 isoform X24

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:13962189
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:947986
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:20982175
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:9471277
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:14152
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:23972474
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:550580
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:348586
      exchanger_TraA; outer membrane exchange protein TraA
    19. XM_006533301.5XP_006533364.1  teneurin-2 isoform X19

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:14672260
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10181057
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21692246
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:358380
      EGF_2; EGF-like domain
      cl18310
      Location:10181348
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:445563
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10152
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24682545
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    20. XM_036156697.1XP_036012590.1  teneurin-2 isoform X22

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:14252218
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:9761015
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21272204
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:9761306
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24262503
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:579609
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:377615
      exchanger_TraA; outer membrane exchange protein TraA
    21. XM_036156694.1XP_036012587.1  teneurin-2 isoform X18

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:14872280
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10381077
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21892266
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:10381368
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24882565
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:377683
      exchanger_TraA; outer membrane exchange protein TraA
    22. XM_036156693.1XP_036012586.1  teneurin-2 isoform X16

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:14962289
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10471086
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21982275
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:10471377
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24972574
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:377692
      exchanger_TraA; outer membrane exchange protein TraA
    23. XM_036156695.1XP_036012588.1  teneurin-2 isoform X20

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:14662259
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10171056
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21682245
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:10171347
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24672544
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:620650
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:418656
      exchanger_TraA; outer membrane exchange protein TraA
    24. XM_036156692.1XP_036012585.1  teneurin-2 isoform X14

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:15282321
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10791118
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:22302307
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:10791409
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:25292606
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:418724
      exchanger_TraA; outer membrane exchange protein TraA
    25. XM_036156691.1XP_036012584.1  teneurin-2 isoform X13

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:15302323
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10881116
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:22322309
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:10881411
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:25312608
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:418733
      exchanger_TraA; outer membrane exchange protein TraA
    26. XM_006533297.5XP_006533360.1  teneurin-2 isoform X12

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:15372330
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10881127
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:22392316
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:428450
      EGF_2; EGF-like domain
      cl18310
      Location:10881418
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:515633
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:25382615
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    27. XM_030245996.2XP_030101856.1  teneurin-2 isoform X23

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (10) summary
      COG3209
      Location:14212214
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:474503
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:9721011
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21232200
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:379405
      EGF_2; EGF-like domain
      cl18310
      Location:9721302
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:470606
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:1177
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24222499
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam18372
      Location:414431
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
    28. XM_017314549.2XP_017170038.1  teneurin-2 isoform X17

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:14922285
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10431082
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21942271
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:383405
      EGF_2; EGF-like domain
      cl18310
      Location:10431373
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:470588
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:1177
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24932570
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    29. XM_017314548.2XP_017170037.1  teneurin-2 isoform X17

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:14922285
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10431082
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:21942271
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:383405
      EGF_2; EGF-like domain
      cl18310
      Location:10431373
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:470588
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:1177
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:24932570
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    30. XM_006533298.3XP_006533361.1  teneurin-2 isoform X15

      See identical proteins and their annotated locations for XP_006533361.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:15272320
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10781117
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:22292306
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:418440
      EGF_2; EGF-like domain
      cl18310
      Location:10781408
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:505623
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:4212
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:25282605
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    31. XM_006533294.5XP_006533357.1  teneurin-2 isoform X5

      See identical proteins and their annotated locations for XP_006533357.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      B9EJ72
      Conserved Domains (8) summary
      COG3209
      Location:16482441
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11991238
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23502427
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:539561
      EGF_2; EGF-like domain
      cl18310
      Location:11991529
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:626744
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26492726
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin