b black [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bprovided by FlyBase
Official Full Name: blackprovided by FlyBase
Primary source: FLYBASE:FBgn0000153
Locus tag: Dmel_CG7811
See related: AllianceGenome:FB:FBgn0000153
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ADC; ADC/CSADC; anon-34Db; B; BG:DS00941.5; Black; cDNA 1; CG7811; DGad2; Dm-ADC; Dmel\CG7811; DmGad2; Gad2; GAD[[2]]
Summary: Enables aspartate 1-decarboxylase activity and sulfinoalanine decarboxylase activity. Involved in visual behavior. Predicted to be active in cytoplasm. Is expressed in adult head; dorsal longitudinal indirect flight muscle cell; lamina; and mesothoracic tergotrochanter muscle cell. Orthologous to several human genes including CSAD (cysteine sulfinic acid decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34D1-34D1; 2-49 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13821248..13823979)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13821248..13823979)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dose-, LET-, and gene-dependent patterns of DNA changes underlying the point mutations in spermatozoa of Drosophila melanogaster. I. Autosomal gene black.
Title: The dose-, LET-, and gene-dependent patterns of DNA changes underlying the point mutations in spermatozoa of Drosophila melanogaster. I. Autosomal gene black.
6 gamma-ray- and one neutron-induced black mutants displayed the small deletions/insertions and transversion (G --> T) which led to the stop-codon in one case
Title: [Radiation biology of structurally different drosophila genes. Report IV. The black gene: sequencing of the "point" mutations and recombination mechanisms of their processing].
Black expression is strictly accompanied by Ebony expression in optic lobes.
Title: Activity and coexpression of Drosophila black with ebony in fly optic lobes reveals putative cooperative tasks in vision that evade electroretinographic detection.
The presence of cysteine inhibited ADC, CSAD and GDC activity.
Title: Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid α-decarboxylases.
Results show that flies with black/DGAD2 mutation are reduced in aspartate decarboxylase activity, and respond abnormally to visual cues.
Title: The Drosophila black enigma: the molecular and behavioural characterization of the black1 mutant allele.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables aspartate 1-decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartate 1-decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables glutamate decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables sulfinoalanine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in beta-alanine biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in developmental pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in uracil catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in visual behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: black

Names: CG7811-PA; CG7811-PB; CG7811-PC; Oregon-R glutamate decarboxylase; aspartate 1-decarboxylase; aspartate decarboxylase; b-PA; b-PB; b-PC; cysteine sulfinic acid decarboxylase; glutamic acid decarboxylase 2

NP_001246025.1

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.11

EC 4.1.1.29

NP_001285910.1

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.11

EC 4.1.1.29

NP_476788.1

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.11

EC 4.1.1.29

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13821248..13823979

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259096.2 → NP_001246025.1 black, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246025.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24062

Conserved Domains (1) summary

cl18945
Location:128 → 499

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_057440.5 → NP_476788.1 black, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476788.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24062

Related

FBpp0080119

Conserved Domains (1) summary

cl18945
Location:128 → 499

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001298981.1 → NP_001285910.1 black, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285910.1

Status: REVIEWED

UniProtKB/TrEMBL

X2J8B3

Conserved Domains (1) summary

cl18945
Location:67 → 438

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...