Jheh1 Juvenile hormone epoxide hydrolase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Jheh1provided by FlyBase
Official Full Name: Juvenile hormone epoxide hydrolase 1provided by FlyBase
Primary source: FLYBASE:FBgn0010053
Locus tag: Dmel_CG15101
See related: AllianceGenome:FB:FBgn0010053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 142196_at; BEST:GH06241; CG15101; Dmel\CG15101; JH; Jheh; JHEH; JHEH 1; jheh1
Summary: Enables juvenile hormone epoxide hydrolase activity. Involved in juvenile hormone catabolic process. Is expressed in adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and fat body/gonad primordium. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18853434..18855087, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14740939..14742592, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables epoxide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ether hydrolase activity	IEA Inferred from Electronic Annotation more info
enables juvenile hormone epoxide hydrolase activity	IDA Inferred from Direct Assay more info
NOT enables peptidase activity	IKR Inferred from Key Residues more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine hydrolase activity	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in epoxide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in juvenile hormone catabolic process	IDA Inferred from Direct Assay more info

Names: CG15101-PA; JH-epoxide hydrolase; Jheh1-PA; juvenile hormone epoxide hydrolase; microsomal apoxide hydrolase

NP_611385.1

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The following sections contain reference sequences that belong to a specific genome build. Explain