cv-2 crossveinless 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cv-2provided by FlyBase
Official Full Name: crossveinless 2provided by FlyBase
Primary source: FLYBASE:FBgn0000395
Locus tag: Dmel_CG15671
See related: AllianceGenome:FB:FBgn0000395
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BMPER; CG15671; CT35855; cv 2; Cv 2; Cv-2; cv2; Cv2; CV2; Dmel\CG15671
Summary: Enables BMP binding activity; BMP receptor binding activity; and heparan sulfate proteoglycan binding activity. Involved in imaginal disc-derived wing vein specification and positive regulation of BMP signaling pathway. Located in extracellular region. Is expressed in several structures, including anterior-posterior compartment boundary of imaginal disc; eye disc posterior to the morphogenetic furrow; notopleural bristle; wing disc; and wing vein. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21355015..21379464, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17242520..17266969, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The bone morphogenetic protein- binding protein Cv-2 negatively regulates bone morphogenetic protein signaling.
Title: A genetic network conferring canalization to a bistable patterning system in Drosophila.
Cv-2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling.
Title: The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables BMP receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables heparan sulfate proteoglycan binding	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain