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    Atf-2 Activating transcription factor-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atf-2provided by FlyBase
    Official Full Name
    Activating transcription factor-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0265193
    Locus tag
    Dmel_CG44246
    See related
    AllianceGenome:FB:FBgn0265193
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atf-2; ATF-2; atf2; Atf2; ATF2; CG12850; CG30420; CG44246; dATF-2; dATF2; DM5; Dmel\CG44246; FBgn0050420
    Old locus tag
    Dmel_CG30420
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; regulation of triglyceride biosynthetic process; and stress-activated MAPK cascade. Located in chromocenter; nucleus; and pericentric heterochromatin. Is expressed in organism. Orthologous to several human genes including ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atf-2 in Genome Data Viewer
    Location:
    60E4-60E4; 2-107 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24870108..24871509)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20757631..20759032)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44829 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43466

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Potential Application of Drosophila melanogaster as a Model Organism in COVID-19-Related Research. Nainu F, et al. Front Pharmacol, 2020. PMID 33013425, Free PMC Article
    2. Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila. Kohyama-Koganeya A, et al. J Lipid Res, 2011 Jul. PMID 21550991, Free PMC Article
    3. Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells. Seong KH, et al. Commun Biol, 2020 May 4. PMID 32367035, Free PMC Article
    4. Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man. Hime GR, et al. World J Psychiatry, 2021 Oct 19. PMID 34733638, Free PMC Article
    5. Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons. Shimizu H, et al. Mol Cell Biol, 2008 Oct. PMID 18694958, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.
      Title: Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.
    2. This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1-p38, disrupts heterochromatin.
      Title: Inheritance of stress-induced, ATF-2-dependent epigenetic change.
    3. dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
      Title: Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons.
    4. ATF-2 is critical for regulation of fat metabolism.
      Title: ATF-2 regulates fat metabolism in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mucosal immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activating transcription factor-2
    Names
    Atf-2-PA
    CG44246-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24870108..24871509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038884.2 → NP_001033973.1  activating transcription factor-2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PE13, Q56H90
      Conserved Domains (1) summary
      pfam07989
      Location:300 → 336
      Cnn_1N; Centrosomin N-terminal motif 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PE13 Q2PE13
    Q56H90 Q56H90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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