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    CG11537 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11537provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035400
    Locus tag
    Dmel_CG11537
    See related
    AllianceGenome:FB:FBgn0035400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11537
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval salivary gland body; and gut section. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A) and MFSD14B (major facilitator superfamily domain containing 14B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11537 in Genome Data Viewer
    Location:
    63B3-63B5; 3-6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3128034..3143457, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3128034..3143457, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene prominin-like Neighboring gene transfer RNA:Methionine-CAT 2-1 Neighboring gene long non-coding RNA:CR45819 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase Neighboring gene Ubiquitin specific protease 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and D. melanogaster. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 32733888, Free PMC Article
    2. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article
    3. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article
    4. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
    5. Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development. Chen YD, et al. Proc Natl Acad Sci U S A, 2023 Aug 8. PMID 37523539, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11537-PA
    CG11537-PB
    CG11537-PC
    CG11537-PD
    CG11537-PE
    CG11537-PF
    CG11537-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3128034..3143457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167989.2 → NP_728812.1  uncharacterized protein Dmel_CG11537, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R24, Q9VZU9
      Related
      FBpp0072978
      Conserved Domains (2) summary
      cd06174
      Location:231 → 587
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:232 → 576
      MFS_1; Major Facilitator Superfamily

    2. NM_001104019.2 → NP_001097489.1  uncharacterized protein Dmel_CG11537, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R24, Q6NLL3
      Conserved Domains (2) summary
      cd06174
      Location:256 → 612
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:257 → 601
      MFS_1; Major Facilitator Superfamily

    3. NM_001104020.2 → NP_001097490.1  uncharacterized protein Dmel_CG11537, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R24, Q6NLL3
      Conserved Domains (2) summary
      cd06174
      Location:256 → 612
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:257 → 601
      MFS_1; Major Facilitator Superfamily

    4. NM_139514.3 → NP_647771.1  uncharacterized protein Dmel_CG11537, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T014
      Related
      FBpp0072977
      Conserved Domains (2) summary
      cd06174
      Location:39 → 395
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:40 → 384
      MFS_1; Major Facilitator Superfamily

    5. NM_167988.2 → NP_728811.1  uncharacterized protein Dmel_CG11537, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R24, Q9VZU9
      Related
      FBpp0072979
      Conserved Domains (2) summary
      cd06174
      Location:231 → 587
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:232 → 576
      MFS_1; Major Facilitator Superfamily

    6. NM_001274425.1 → NP_001261354.1  uncharacterized protein Dmel_CG11537, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R24, Q6NLL3
      Conserved Domains (2) summary
      cd06174
      Location:256 → 612
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:257 → 601
      MFS_1; Major Facilitator Superfamily

    7. NM_001259659.1 → NP_001246588.1  uncharacterized protein Dmel_CG11537, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH78, M9NDY4
      Conserved Domains (2) summary
      cd06174
      Location:231 → 587
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:232 → 576
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDY4 M9NDY4
    Q6NLL3 Q6NLL3
    Q8T014 Q8T014
    Q9VZU9 Q9VZU9

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