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    Adnp activity-dependent neuroprotective protein [ Mus musculus (house mouse) ]

    Gene ID: 11538, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adnpprovided by MGI
    Official Full Name
    activity-dependent neuroprotective proteinprovided by MGI
    Primary source
    MGI:MGI:1338758
    See related
    Ensembl:ENSMUSG00000051149 AllianceGenome:MGI:1338758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0784
    Summary
    This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 36.2), CNS E14 (RPKM 35.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adnp in Genome Data Viewer
    Location:
    2 H3; 2 88.41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168022885..168049032, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168180965..168207112, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06455 Neighboring gene predicted gene, 33185 Neighboring gene predicted gene, 54130 Neighboring gene predicted gene 20716 Neighboring gene STARR-seq mESC enhancer starr_06457 Neighboring gene STARR-positive B cell enhancer ABC_E10163 Neighboring gene STARR-positive B cell enhancer ABC_E8797 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 1, catalytic Neighboring gene molybdenum cofactor synthesis 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Gm20716

    Readthrough gene: Gm20716, Included gene: Dpm1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular nitric oxide homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular nitric oxide homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to carbohydrate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in short-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in short-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    activity-dependent neuroprotector homeobox protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310086.1NP_001297015.1  activity-dependent neuroprotector homeobox protein isoform 1

      See identical proteins and their annotated locations for NP_001297015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AK134786, BC090840, BF464091, BG143403, BX005039
      Consensus CDS
      CCDS38342.1
      UniProtKB/Swiss-Prot
      A2BDX0, Q9Z103
      UniProtKB/TrEMBL
      Q3UYC8
      Related
      ENSMUSP00000056809.5, ENSMUST00000057793.11
      Conserved Domains (2) summary
      smart00389
      Location:767810
      HOX; Homeodomain
      sd00020
      Location:490509
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001310088.1NP_001297017.1  activity-dependent neuroprotector homeobox protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons, lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI448578, AK134786, BC090840, BG143403, BX005039
      UniProtKB/TrEMBL
      Q5RKY4
      Conserved Domains (3) summary
      smart00389
      Location:539582
      HOX; Homeodomain
      sd00020
      Location:262281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam19627
      Location:1525
      ADNP_N; Activity-dependent neuroprotector homeobox protein N-terminal
    3. NM_009628.3NP_033758.2  activity-dependent neuroprotector homeobox protein isoform 1

      See identical proteins and their annotated locations for NP_033758.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AK134786, BC090840, BF460813, BG143403, BX005039
      Consensus CDS
      CCDS38342.1
      UniProtKB/Swiss-Prot
      A2BDX0, Q9Z103
      UniProtKB/TrEMBL
      Q3UYC8
      Related
      ENSMUSP00000085316.6, ENSMUST00000088001.6
      Conserved Domains (2) summary
      smart00389
      Location:767810
      HOX; Homeodomain
      sd00020
      Location:490509
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      168022885..168049032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)