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    Wdr13 WD repeat domain 13 [ Mus musculus (house mouse) ]

    Gene ID: 73447, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr13provided by MGI
    Official Full Name
    WD repeat domain 13provided by MGI
    Primary source
    MGI:MGI:1914661
    See related
    Ensembl:ENSMUSG00000031166 AllianceGenome:MGI:1914661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mMg21; DXHXS7467e; 1700060B08Rik; 5730411P10Rik
    Summary
    Enables promoter-specific chromatin binding activity. Acts upstream of or within negative regulation of type B pancreatic cell proliferation. Predicted to be located in centriolar satellite; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to human WDR13 (WD repeat domain 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 49.2), frontal lobe adult (RPKM 36.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wdr13 in Genome Data Viewer
    Location:
    X A1.1; X 3.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7989540..7999134, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8123301..8132858, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Wiskott-Aldrich syndrome Neighboring gene STARR-seq mESC enhancer starr_46687 Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 7, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E7686 Neighboring gene RNA binding motif (RNP1, RRM) protein 3 Neighboring gene RNA binding motif protein 3, opposite strand Neighboring gene TBC1 domain family, member 25 Neighboring gene STARR-seq mESC enhancer starr_46689

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117822, MGC158990

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 13
    Names
    memory-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290783.1NP_001277712.1  WD repeat-containing protein 13 isoform 2

      See identical proteins and their annotated locations for NP_001277712.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AL663032, BC057366, BC080853
      Consensus CDS
      CCDS72338.1
      UniProtKB/TrEMBL
      Q8K412, Q9CYL7, S4R225
      Conserved Domains (2) summary
      COG2319
      Location:73393
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:129165
      7WD40; WD40 repeat [structural motif]
    2. NM_026137.5NP_080413.2  WD repeat-containing protein 13 isoform 1

      See identical proteins and their annotated locations for NP_080413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK017549, AL663032, BC057366, BC080853
      Consensus CDS
      CCDS29986.1
      UniProtKB/Swiss-Prot
      Q91V09
      UniProtKB/TrEMBL
      Q32P16, Q8K412, Q9CYL7
      Related
      ENSMUSP00000033506.7, ENSMUST00000033506.13
      Conserved Domains (2) summary
      COG2319
      Location:165485
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221257
      7WD40; WD40 repeat [structural motif]
    3. NM_028542.1NP_082818.1  WD repeat-containing protein 13 isoform 2

      See identical proteins and their annotated locations for NP_082818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AK006837, AL663032, BC057366, BC080853, CF739215
      Consensus CDS
      CCDS72338.1
      UniProtKB/TrEMBL
      Q8K412, Q9CYL7, S4R225
      Related
      ENSMUSP00000138468.2, ENSMUST00000130832.8
      Conserved Domains (2) summary
      COG2319
      Location:73393
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:129165
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7989540..7999134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527703.4XP_006527766.1  WD repeat-containing protein 13 isoform X1

      See identical proteins and their annotated locations for XP_006527766.1

      UniProtKB/Swiss-Prot
      Q91V09
      UniProtKB/TrEMBL
      Q32P16, Q8K412, Q9CYL7
      Related
      ENSMUSP00000111286.2, ENSMUST00000115623.8
      Conserved Domains (2) summary
      COG2319
      Location:165485
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221257
      7WD40; WD40 repeat [structural motif]
    2. XM_036162112.1XP_036018005.1  WD repeat-containing protein 13 isoform X3

      Conserved Domains (2) summary
      COG2319
      Location:43363
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:99135
      7WD40; WD40 repeat [structural motif]
    3. XM_036162110.1XP_036018003.1  WD repeat-containing protein 13 isoform X1

      UniProtKB/Swiss-Prot
      Q91V09
      UniProtKB/TrEMBL
      Q32P16, Q8K412, Q9CYL7
      Conserved Domains (2) summary
      COG2319
      Location:165485
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221257
      7WD40; WD40 repeat [structural motif]
    4. XM_036162111.1XP_036018004.1  WD repeat-containing protein 13 isoform X2

      UniProtKB/TrEMBL
      Q8K412, Q9CYL7, S4R225
      Conserved Domains (2) summary
      COG2319
      Location:73393
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:129165
      7WD40; WD40 repeat [structural motif]