U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ccni cyclin I [ Mus musculus (house mouse) ]

    Gene ID: 12453, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ccniprovided by MGI
    Official Full Name
    cyclin Iprovided by MGI
    Primary source
    MGI:MGI:1341077
    See related
    Ensembl:ENSMUSG00000063015 AllianceGenome:MGI:1341077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebellum and retina layer. Orthologous to human CCNI (cyclin I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 56.6), colon adult (RPKM 53.2) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ccni in Genome Data Viewer
    Location:
    5 E2; 5 47.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (93329796..93354348, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (93181933..93206495, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22915 Neighboring gene septin 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93522357-93522466 Neighboring gene STARR-seq mESC enhancer starr_13664 Neighboring gene VISTA enhancer mm39 Neighboring gene RIKEN cDNA 2010109A12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93635715-93635902 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene predicted gene, 42116

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Assignment of the cyclin I gene (Ccni) to mouse chromosome 5E3.3-F1. 3 by in situ hybridization. Jensen MR, et al. Cytogenet Cell Genet, 1998. PMID 10072591
    2. In vivo expression and genomic organization of the mouse cyclin I gene (Ccni). Jensen MR, et al. Gene, 2000 Oct 3. PMID 11054536
    3. Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes. Taniguchi Y, et al. Am J Physiol Renal Physiol, 2012 May 1. PMID 22262481, Free PMC Article
    4. Cyclin I and p35 determine the subcellular distribution of Cdk5. Hagmann H, et al. Am J Physiol Cell Physiol, 2015 Feb 15. PMID 25500740
    5. Cyclin I protects podocytes from apoptosis. Griffin SV, et al. J Biol Chem, 2006 Sep 22. PMID 16847066

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Subcellular localization of Cdk5 is determined by its specific activators, cyclin I and p35.
      Title: Cyclin I and p35 determine the subcellular distribution of Cdk5.
    2. Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes.
      Title: Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes.
    3. Cyclin I protects podocytes from apoptosis, and we provide preliminary data to suggest that this is mediated by stabilization of p21(Cip1/Waf1).
      Title: Cyclin I protects podocytes from apoptosis.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cyclin-I

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420723.1 → NP_001407652.1  cyclin-I

      Status: VALIDATED

      Source sequence(s)
      AC134827
      UniProtKB/Swiss-Prot
      G3X985, Q9Z2V9
      UniProtKB/TrEMBL
      Q8C7E2, Q99LF2

    2. NM_017367.4 → NP_059063.2  cyclin-I

      See identical proteins and their annotated locations for NP_059063.2

      Status: VALIDATED

      Source sequence(s)
      AC134827
      Consensus CDS
      CCDS19436.1
      UniProtKB/Swiss-Prot
      G3X985, Q9Z2V9
      UniProtKB/TrEMBL
      Q8C7E2, Q99LF2
      Related
      ENSMUSP00000050189.9, ENSMUST00000058550.15
      Conserved Domains (1) summary
      pfam00134
      Location:39 → 142
      Cyclin_N; Cyclin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      93329796..93354348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254086.2 → XP_030109946.1  cyclin-I isoform X2

      UniProtKB/TrEMBL
      Q8C7E2
      Conserved Domains (1) summary
      pfam00134
      Location:27 → 130
      Cyclin_N; Cyclin, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2V9.4 GenPept UniProtKB/Swiss-Prot:Q9Z2V9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools