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    Vps13B Vacuolar protein sorting 13B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43550, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps13Bprovided by FlyBase
    Official Full Name
    Vacuolar protein sorting 13Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039727
    Locus tag
    Dmel_CG15523
    See related
    AllianceGenome:FB:FBgn0039727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15523; Dmel\CG15523
    Summary
    Predicted to be involved in protein targeting to vacuole. Predicted to be extrinsic component of membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Cohen syndrome. Orthologous to human VPS13B (vacuolar protein sorting 13 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps13B in Genome Data Viewer
    Location:
    99C7-99C7; 3-99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29935978..29948207)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25761700..25773929)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit alpha Neighboring gene Component of oligomeric golgi complex 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tachykinin-like receptor at 99D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Anding AL, et al. Curr Biol, 2018 Jan 22. PMID 29307555, Free PMC Article
    2. Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster. Gradilla AC, et al. Genetics, 2011 Nov. PMID 21900267, Free PMC Article
    3. Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. Esslinger SM, et al. RNA Biol, 2013 Jun. PMID 23669073, Free PMC Article
    4. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    5. In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor. Baker FC, et al. Development, 2021 Nov 15. PMID 35020877, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to vacuole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extrinsic component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting 13B
    Names
    CG15523-PA
    CG15523-PB
    Vps13B-PA
    Vps13B-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29935978..29948207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143496.4 → NP_651753.2  vacuolar protein sorting 13B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651753.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAD3
      Conserved Domains (3) summary
      pfam09333
      Location:3473 → 3546
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:5 → 117
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam16909
      Location:3319 → 3468
      VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal

    2. NM_206587.2 → NP_996310.2  vacuolar protein sorting 13B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996310.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RKY3
      Conserved Domains (2) summary
      pfam12624
      Location:5 → 117
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam16908
      Location:135 → 203
      VPS13; Vacuolar sorting-associated protein 13, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RKY3 Q1RKY3
    Q9VAD3 Q9VAD3

    Gene LinkOut

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