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    Mfap1 Microfibril-associated protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfap1provided by FlyBase
    Official Full Name
    Microfibril-associated protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035294
    Locus tag
    Dmel_CG1017
    See related
    AllianceGenome:FB:FBgn0035294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1017; Dmel\CG1017; dmfap1; mfap1
    Summary
    Involved in mRNA splicing, via spliceosome and regulation of G2/M transition of mitotic cell cycle. Part of protein-containing complex. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human MFAP1 (microfibril associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mfap1 in Genome Data Viewer
    Location:
    62B11-62B11; 3-1.0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1941068..1942872)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1941068..1942872)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44536 Neighboring gene mutator 2 Neighboring gene Centrobin Neighboring gene mauve Neighboring gene antisense RNA:CR45827 Neighboring gene antisense RNA:CR45828 Neighboring gene Succinyl-CoA:3-ketoacid CoA transferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The spliceosome-associated protein Mfap1 binds to VCP in Drosophila. Rode S, et al. PLoS One, 2017. PMID 28837687, Free PMC Article
    2. The genomic response of the Drosophila embryo to JNK signaling. Jasper H, et al. Dev Cell, 2001 Oct. PMID 11703947
    3. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
    4. Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA). Housden BE, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29183982, Free PMC Article
    5. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Microfibril-associated protein 1
    Names
    CG1017-PA
    Mfap1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1941068..1942872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139422.3 → NP_647679.1  Microfibril-associated protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W062
      Related
      FBpp0072720
      Conserved Domains (1) summary
      pfam06991
      Location:233 → 437
      MFAP1; Microfibril-associated/Pre-mRNA processing
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W062.1 Q9W062

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