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    Mvd Mevalonate diphosphate decarboxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32520, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mvdprovided by FlyBase
    Official Full Name
    Mevalonate diphosphate decarboxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030683
    Locus tag
    Dmel_CG8239
    See related
    AllianceGenome:FB:FBgn0030683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8239; Dmel\CG8239; MevPPD; MVD
    Summary
    Predicted to enable diphosphomevalonate decarboxylase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be active in cytosol. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; central brain anlage; epithelium; and gut section. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Mvd in Genome Data Viewer
    Location:
    13E14-13E14; 1-51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15749166..15751737)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15643199..15645770)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 6 Neighboring gene GTPase regulator associated with FAK Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. Strutt H, et al. PLoS Genet, 2013. PMID 23874239, Free PMC Article
    2. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
    3. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? Metta M, et al. BMC Evol Biol, 2010 Apr 28. PMID 20426838, Free PMC Article
    4. Genome-wide assessment of AU-rich elements by the AREScore algorithm. Spasic M, et al. PLoS Genet, 2012 Jan. PMID 22242014, Free PMC Article
    5. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables diphosphomevalonate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphomevalonate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diphosphomevalonate decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mevalonate diphosphate decarboxylase
    Names
    CG8239-PA
    CG8239-PB
    Mvd-PA
    Mvd-PB
    diphosphomevalonate decarboxylase
    NP_001285295.1
    NP_573068.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15749166..15751737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298366.1 → NP_001285295.1  mevalonate diphosphate decarboxylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXQ3
      Conserved Domains (2) summary
      PLN02407
      Location:1 → 322
      PLN02407; diphosphomevalonate decarboxylase
      pfam08544
      Location:231 → 323
      GHMP_kinases_C; GHMP kinases C terminal

    2. NM_132840.5 → NP_573068.3  mevalonate diphosphate decarboxylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573068.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXQ3
      Related
      FBpp0073903
      Conserved Domains (2) summary
      PLN02407
      Location:1 → 322
      PLN02407; diphosphomevalonate decarboxylase
      pfam08544
      Location:231 → 323
      GHMP_kinases_C; GHMP kinases C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXQ3 Q9VXQ3

    Gene LinkOut

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