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    Arts Artemis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Artsprovided by FlyBase
    Official Full Name
    Artemisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042177
    Locus tag
    Dmel_CG32164
    See related
    AllianceGenome:FB:FBgn0042177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18219; CG18860; CG32164; Dmel\CG32164
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; organism; ovary; and spermatozoon. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arts in Genome Data Viewer
    Location:
    73B1-73B1; 3-44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16602851..16608146)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16596153..16601246)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene spindle defective 2 Neighboring gene Apollo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Proteasome beta6 subunit Neighboring gene Suppressor of ref(2)P sterility

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sexual conflict drive in the rapid evolution of new gametogenesis genes. VanKuren NW, et al. Semin Cell Dev Biol, 2024 Jun-Jul. PMID 38309142
    2. Gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions. VanKuren NW, et al. Nat Ecol Evol, 2018 Apr. PMID 29459709, Free PMC Article
    3. APOLLO, a testis-specific Drosophila ortholog of importin-4, mediates the loading of protamine-like protein Mst77F into sperm chromatin. Emelyanov AV, et al. J Biol Chem, 2023 Oct. PMID 37660905, Free PMC Article
    4. Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila. Borkúti P, et al. Front Mol Biosci, 2022. PMID 36060241, Free PMC Article
    5. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    artemis
    Names
    Arts-PA
    Arts-PB
    Arts-PC
    CG32164-PA
    CG32164-PB
    CG32164-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16602851..16608146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001414077.1 → NP_001401038.1  artemis, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFR8, Q8SWQ9

    2. NM_001275028.1 → NP_001261957.1  artemis, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261957.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFR8, Q8SWQ9
      Conserved Domains (2) summary
      smart00913
      Location:29 → 90
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:356 → 384
      HEAT; HEAT repeat [structural motif]

    3. NM_168677.2 → NP_730184.1  artemis, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWQ9, Q9VV82
      Related
      FBpp0075073
      Conserved Domains (2) summary
      smart00913
      Location:29 → 90
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:355 → 383
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFR8 M9PFR8
    Q8SWQ9 Q8SWQ9
    Q8T094 Q8T094
    Q9VV82 Q9VV82

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