Cenpc1 centromere protein C1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cenpc1provided by MGI
Official Full Name: centromere protein C1provided by MGI
Primary source: MGI:MGI:99700
See related: Ensembl:ENSMUSG00000029253 AllianceGenome:MGI:99700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cenpc; CENP-C
Summary: This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression: Broad expression in CNS E11.5 (RPKM 7.5), CNS E14 (RPKM 5.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86159877..86214325, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86012018..86065962, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parallel pathways for recruiting effector proteins determine centromere drive and suppression.
Title: Parallel pathways for recruiting effector proteins determine centromere drive and suppression.
Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice.
Title: Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
Title: Kif4 Is Essential for Mouse Oocyte Meiosis.
CENP-C works as an important factor for centromeric M18BP1 recruitment
Title: CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

32.MHAa56g8.seq (e-PCR)
- UniSTS:123969

PMC18698P1 (e-PCR)
- UniSTS:271719

PMC18698P2 (e-PCR)
- UniSTS:271720

U03113 (e-PCR)
- UniSTS:159386

AU022245 (e-PCR)
- UniSTS:207826

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables centromeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables centromeric DNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome segregation	NAS Non-traceable Author Statement more info	PubMed
involved_in kinetochore assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle attachment to meiosis I kinetochore	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: centromere protein C

Names: centromere autoantigen C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001345902.1 → NP_001332831.1 centromere protein C isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC101846, AC107634, AK143566, BC150700, BY718033

UniProtKB/Swiss-Prot

P49452

UniProtKB/TrEMBL

Q3UPF6
NM_001345903.1 → NP_001332832.1 centromere protein C isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC101846, AC107634, AK143566, BC150700, BY718033

UniProtKB/Swiss-Prot

P49452

UniProtKB/TrEMBL

Q3UPF6
NM_001345904.1 → NP_001332833.1 centromere protein C isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC101846, AC107634, AK143566, BC150700, BY718033

UniProtKB/Swiss-Prot

P49452

UniProtKB/TrEMBL

Q3UPF6

Conserved Domains (2) summary

pfam15620
Location:2 → 255

CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region

cl21464
Location:555 → 639

cupin_like; Conserved domain found in cupin and related proteins
NM_001421563.1 → NP_001408492.1 centromere protein C isoform 5

Status: REVIEWED

Source sequence(s)

AC101846, AC107634
NM_001421564.1 → NP_001408493.1 centromere protein C isoform 4

Status: REVIEWED

Source sequence(s)

AC101846, AC107634
NM_007683.4 → NP_031709.2 centromere protein C isoform 2

See identical proteins and their annotated locations for NP_031709.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC101846, AC107634, AK143566, BC150700, BY718033

Consensus CDS

CCDS39123.1

UniProtKB/Swiss-Prot

B9EK81, P49452

Related

ENSMUSP00000031170.9, ENSMUST00000031170.10

Conserved Domains (3) summary

pfam15620
Location:266 → 519

CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region

pfam15622
Location:7 → 261

CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal

cl21464
Location:819 → 903

cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

86159877..86214325 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254095.2 → XP_030109955.1 centromere protein C isoform X1

Conserved Domains (3) summary

pfam15620
Location:355 → 608

CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region

pfam15622
Location:110 → 350

CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal

cl21464
Location:889 → 973

cupin_like; Conserved domain found in cupin and related proteins
XM_017320638.3 → XP_017176127.1 centromere protein C isoform X5

Conserved Domains (2) summary

pfam15620
Location:2 → 255

CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region

cl21464
Location:555 → 639

cupin_like; Conserved domain found in cupin and related proteins
XM_030254096.2 → XP_030109956.1 centromere protein C isoform X2

Conserved Domains (3) summary

pfam15620
Location:355 → 608

CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region

pfam15622
Location:110 → 350

CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal

cl21464
Location:908 → 942

cupin_like; Conserved domain found in cupin and related proteins
XM_017320636.3 → XP_017176125.1 centromere protein C isoform X3

Conserved Domains (3) summary

pfam15620
Location:266 → 519

CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region

pfam15622
Location:7 → 261

CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal

cl21464
Location:819 → 853

cupin_like; Conserved domain found in cupin and related proteins