U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Piezo piezo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34112, updated on 17-Dec-2024

    Summary

    Official Symbol
    Piezoprovided by FlyBase
    Official Full Name
    piezoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264953
    Locus tag
    Dmel_CG44122
    See related
    AllianceGenome:FB:FBgn0264953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.32; CG18103; CG31608; CG44122; CG8486; clone 1.32; Dmel\CG44122; Dmpiezo; DmPiezo; DmPIEZO; fos28F; fos500; OrfKD; piezo
    Old locus tag
    Dmel_CG18103; Dmel_CG8486
    Summary
    Enables mechanosensitive monoatomic ion channel activity. Involved in several processes, including cellular response to mechanical stimulus; detection of temperature stimulus involved in sensory perception of pain; and mechanosensory behavior. Located in plasma membrane. Is expressed in several structures, including antennal primordium; epithelium; head epidermis primordium; larval imaginal tissue; and sensory neurons. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1; distal arthrogryposis type 3; distal arthrogryposis type 5; and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)) and PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Piezo in Genome Data Viewer
    Location:
    28E9-28F1; 2-30 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8163073..8190137)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8163073..8190137)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatidic Acid Phospholipase A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rabenosyn-5 Neighboring gene Acyl-CoA binding protein 1 Neighboring gene antisense RNA:CR44116 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in membrane  
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    piezo
    Names
    CG44122-PE
    CG44122-PF
    CG44122-PG
    CG44122-PH
    CG44122-PI
    CG44122-PJ
    CG44122-PK
    CG44122-PL
    CG44122-PM
    CG44122-PO
    CG44122-PP
    Piezo-PE
    Piezo-PF
    Piezo-PG
    Piezo-PH
    Piezo-PI
    Piezo-PJ
    Piezo-PK
    Piezo-PL
    Piezo-PM
    Piezo-PO
    Piezo-PP
    dmpiezo
    fos-related gene at 28F

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8163073..8190137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273297.1 → NP_001260226.1  piezo, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF50
      Conserved Domains (2) summary
      pfam12166
      Location:2109 → 2539
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1319 → 1513
      PIEZO; Piezo
    2. NM_164795.6 → NP_723354.3  piezo, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723354.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG4
      Conserved Domains (2) summary
      pfam12166
      Location:2247 → 2677
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1300 → 1494
      PIEZO; Piezo
    3. NM_001042881.5 → NP_001036346.3  piezo, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036346.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8L0
      Conserved Domains (2) summary
      pfam12166
      Location:2209 → 2639
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1300 → 1494
      PIEZO; Piezo
    4. NM_001273298.1 → NP_001260227.1  piezo, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB69
      Conserved Domains (2) summary
      pfam12166
      Location:2089 → 2519
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1248 → 1420
      PIEZO; Piezo
    5. NM_001201789.2 → NP_001188718.1  piezo, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRE5
      Conserved Domains (2) summary
      pfam12166
      Location:2108 → 2538
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1245 → 1439
      PIEZO; Piezo
    6. NM_001316385.1 → NP_001303314.1  piezo, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WGQ9
      Conserved Domains (2) summary
      pfam12166
      Location:2511 → 2941
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1363
      PIEZO; Piezo
    7. NM_001273300.2 → NP_001260229.2  piezo, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCW8
      Conserved Domains (2) summary
      pfam12166
      Location:2376 → 2806
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1363
      PIEZO; Piezo
    8. NM_001169436.3 → NP_001162907.1  piezo, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHB4
      Conserved Domains (2) summary
      pfam12166
      Location:2224 → 2654
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1420
      PIEZO; Piezo
    9. NM_001273299.1 → NP_001260228.1  piezo, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCC7
      Conserved Domains (2) summary
      pfam12166
      Location:2071 → 2501
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1420
      PIEZO; Piezo
    10. NM_001201790.2 → NP_001188719.1  piezo, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H6X2P4, M9MSG8
      Conserved Domains (2) summary
      pfam12166
      Location:2089 → 2519
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1226 → 1420
      PIEZO; Piezo
    11. NM_135344.6 → NP_609188.4  piezo, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609188.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLS3
      Conserved Domains (2) summary
      pfam12166
      Location:2159 → 2589
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1245 → 1439
      PIEZO; Piezo
    External link. Please review our privacy policy.