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    Cnb Centrobin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38258, updated on 17-Dec-2024

    Summary

    Official Symbol
    Cnbprovided by FlyBase
    Official Full Name
    Centrobinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035295
    Locus tag
    Dmel_CG5690
    See related
    AllianceGenome:FB:FBgn0035295
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-62BCa; cDNA C; CG5690; cnb; CNB; Dmel\CG5690
    Summary
    Involved in interphase microtubule organizing center assembly and protein localization to centrosome. Located in centriole. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic dorsal epidermis; embryonic/larval midgut primordium; larval somatic muscle cell; and mesoderm. Orthologous to human CNTROB (centrobin, centriole duplication and spindle assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Cnb in Genome Data Viewer
    Location:
    62B11-62B11; 3-1.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1947565..1950262)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1947565..1950262)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44536 Neighboring gene Microfibril-associated protein 1 Neighboring gene mutator 2 Neighboring gene mauve Neighboring gene antisense RNA:CR45827 Neighboring gene antisense RNA:CR45828 Neighboring gene Succinyl-CoA:3-ketoacid CoA transferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in centriole replication  
    involved_in centriole replication  
    involved_in centriole replication  
    involved_in centrosome separation  
    involved_in interphase microtubule organizing center assembly PubMed 
    involved_in mitotic cytokinetic process  
    involved_in protein localization to centrosome PubMed 
    involved_in regulation of cilium assembly  
    Component Evidence Code Pubs
    is_active_in centriole  
    located_in centriole PubMed 
    is_active_in centrosome  

    General protein information

    Preferred Names
    centrobin
    Names
    CG5690-PA
    CG5690-PB
    Cnb-PA
    Cnb-PB
    centronobin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1947565..1950262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139423.3 → NP_647680.1  centrobin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D2, Q9I7U5
      Related
      FBpp0072721
      Conserved Domains (3) summary
      pfam00261
      Location:349 → 563
      Tropomyosin; Tropomyosin
      pfam07926
      Location:291 → 408
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam08702
      Location:349 → 458
      Fib_alpha; Fibrinogen alpha/beta chain family
    2. NM_001274371.1 → NP_001261300.1  centrobin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D2, Q9I7U5
      Conserved Domains (3) summary
      pfam00261
      Location:349 → 563
      Tropomyosin; Tropomyosin
      pfam07926
      Location:291 → 408
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam08702
      Location:349 → 458
      Fib_alpha; Fibrinogen alpha/beta chain family
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