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    Dcr-2 Dicer-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36993, updated on 17-Dec-2024

    Summary

    Official Symbol
    Dcr-2provided by FlyBase
    Official Full Name
    Dicer-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034246
    Locus tag
    Dmel_CG6493
    See related
    AllianceGenome:FB:FBgn0034246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6493; CG6493; dcr; Dcr; dcr-2; DCR-2; dcr2; Dcr2; DCR2; dDcr2; dic2; dicer; Dicer; DICER; dicer-2; DICER-2; Dicer-II; dicer2; Dicer2; dmDcr-2; DmDcr-2; Dmel\CG6493
    Summary
    Enables several functions, including ATP hydrolysis activity; RNA binding activity; and ribonuclease III activity. Involved in several processes, including negative regulation of gene expression; regulation of defense response; and response to virus. Located in nucleus and perinuclear region of cytoplasm. Part of RISC complex and RISC-loading complex. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Dcr-2 in Genome Data Viewer
    Location:
    54C10-54C10; 2-83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17574979..17581525, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13462484..13469030, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rab4 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45274

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity PubMed 
    enables ATP-dependent activity, acting on RNA PubMed 
    enables RNA binding  
    enables RNA binding  
    enables deoxyribonuclease I activity  
    enables mRNA 3'-UTR binding PubMed 
    enables protein binding PubMed 
    enables ribonuclease III activity  
    enables ribonuclease III activity PubMed 
    enables ribonuclease III activity  
    enables ribonuclease III activity PubMed 
    enables siRNA binding PubMed 
    Process Evidence Code Pubs
    involved_in RISC complex assembly PubMed 
    involved_in RISC complex assembly PubMed 
    involved_in RNA processing  
    involved_in RNAi-mediated antiviral immune response PubMed 
    involved_in apoptotic DNA fragmentation  
    involved_in cellular response to virus PubMed 
    involved_in defense response to virus PubMed 
    involved_in detection of virus PubMed 
    involved_in dosage compensation by hyperactivation of X chromosome PubMed 
    involved_in global gene silencing by mRNA cleavage PubMed 
    involved_in heterochromatin formation PubMed 
    involved_in lncRNA catabolic process PubMed 
    involved_in locomotory behavior PubMed 
    involved_in positive regulation of Toll signaling pathway PubMed 
    involved_in positive regulation of defense response to virus by host PubMed 
    involved_in positive regulation of innate immune response PubMed 
    NOT involved_in pre-miRNA processing PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing PubMed 
    involved_in siRNA processing  
    involved_in siRNA processing PubMed 
    involved_in siRNA processing PubMed 
    Component Evidence Code Pubs
    part_of RISC complex PubMed 
    part_of RISC-loading complex  
    part_of RISC-loading complex PubMed 
    part_of RISC-loading complex PubMed 
    part_of RISC-loading complex PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    Dicer-2
    Names
    CG6493-PA
    CG6493-PB
    Dcr-2-PA
    Dcr-2-PB
    Dicer2
    dicer
    dicer 2
    dicer-2
    NP_001286540.1
    NP_523778.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17574979..17581525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299611.1 → NP_001286540.1  Dicer-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFK8, Q2Q3W0
      Conserved Domains (9) summary
      smart00490
      Location:438 → 495
      HELICc; helicase superfamily c-terminal domain
      smart00949
      Location:842 → 1003
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      COG0571
      Location:1432 → 1718
      Rnc; dsRNA-specific ribonuclease [Transcription]
      COG1111
      Location:6 → 542
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:22 → 173
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:1447 → 1648
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd15903
      Location:241 → 343
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00035
      Location:1652 → 1716
      dsrm; Double-stranded RNA binding motif
      pfam03368
      Location:572 → 665
      Dicer_dimer; Dicer dimerization domain
    2. NM_079054.5 → NP_523778.2  Dicer-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523778.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAW0, Q95YG3
      UniProtKB/TrEMBL
      Q2Q3W0
      Related
      FBpp0086061
      Conserved Domains (9) summary
      smart00490
      Location:438 → 495
      HELICc; helicase superfamily c-terminal domain
      smart00949
      Location:843 → 1004
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      COG0571
      Location:1433 → 1719
      Rnc; dsRNA-specific ribonuclease [Transcription]
      COG1111
      Location:6 → 542
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:22 → 173
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:1448 → 1649
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd15903
      Location:241 → 343
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00035
      Location:1653 → 1717
      dsrm; Double-stranded RNA binding motif
      pfam03368
      Location:572 → 665
      Dicer_dimer; Dicer dimerization domain
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