Tnpo Transportin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tnpoprovided by FlyBase
Official Full Name: Transportinprovided by FlyBase
Primary source: FLYBASE:FBgn0024921
Locus tag: Dmel_CG7398
See related: AllianceGenome:FB:FBgn0024921
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7398; Dmel\CG7398; dTnpo; dTNPO; dTrn; dTRN; IMPbeta2; Kapbeta2; Tm; Trn; TRN; Trn1
Summary: Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus; larval lymph gland hemopoiesis; and positive regulation of smoothened signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Used to study intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to several human genes including TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 65A8-65A8; 3-16 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6193480..6200385)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6186580..6193485)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
Title: TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0687 (e-PCR)
- UniSTS:53931

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transportin

Names: CG7398-PA; CG7398-PB; CG7398-PC; CG7398-PD; Karyopherin-beta2; Tnpo-PA; Tnpo-PB; Tnpo-PC; Tnpo-PD; transportin-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6193480..6200385

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058020.4 → NP_477368.1 transportin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477368.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86PD5, Q9VRV8

Related

FBpp0076708

Conserved Domains (5) summary

cd00020
Location:127 → 234

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam03810
Location:32 → 99

IBN_N; Importin-beta N-terminal domain

pfam13513
Location:415 → 469

HEAT_EZ; HEAT-like repeat

pfam13646
Location:399 → 507

HEAT_2; HEAT repeats

sd00044
Location:127 → 155

HEAT; HEAT repeat [structural motif]
NM_001274543.1 → NP_001261472.1 transportin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261472.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86PD5, Q9VRV8

Conserved Domains (5) summary

cd00020
Location:127 → 234

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam03810
Location:32 → 99

IBN_N; Importin-beta N-terminal domain

pfam13513
Location:415 → 469

HEAT_EZ; HEAT-like repeat

pfam13646
Location:399 → 507

HEAT_2; HEAT repeats

sd00044
Location:127 → 155

HEAT; HEAT repeat [structural motif]
NM_168160.2 → NP_729154.1 transportin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729154.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86PD5, Q9VRV8

Related

FBpp0076709

Conserved Domains (5) summary

cd00020
Location:127 → 234

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam03810
Location:32 → 99

IBN_N; Importin-beta N-terminal domain

pfam13513
Location:415 → 469

HEAT_EZ; HEAT-like repeat

pfam13646
Location:399 → 507

HEAT_2; HEAT repeats

sd00044
Location:127 → 155

HEAT; HEAT repeat [structural motif]
NM_168161.2 → NP_729155.1 transportin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729155.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86PD5, Q9VRV8

Related

FBpp0076710

Conserved Domains (5) summary

cd00020
Location:127 → 234

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam03810
Location:32 → 99

IBN_N; Importin-beta N-terminal domain

pfam13513
Location:415 → 469

HEAT_EZ; HEAT-like repeat

pfam13646
Location:399 → 507

HEAT_2; HEAT repeats

sd00044
Location:127 → 155

HEAT; HEAT repeat [structural motif]