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    stwl stonewall [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39581, updated on 17-Dec-2024

    Summary

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    Official Symbol
    stwlprovided by FlyBase
    Official Full Name
    stonewallprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003459
    Locus tag
    Dmel_CG3836
    See related
    AllianceGenome:FB:FBgn0003459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    84; CG3836; Dmel\CG3836; fs(3)02024; snw; Stwl
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including DNA protection; female germ-line stem cell population maintenance; and larval lymph gland hemopoiesis. Located in nucleolus. Colocalizes with polytene chromosome. Is expressed in several structures, including adult brain cell body rind; adult heart; epithelial cell; germarium region 1; and germline cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stwl in Genome Data Viewer
    Location:
    70D6-70D7; 3-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14402930..14409939, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14396030..14403039, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45233 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46032 Neighboring gene uncharacterized protein Neighboring gene big bang

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations of stonewall disrupt the maintenance of female germline stem cells in Drosophila melanogaster. Akiyama T. Dev Growth Differ, 2002 Apr. PMID 11940096
    2. Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis. Kotb NM, et al. Genes Dev, 2024 Jun 25. PMID 38866556, Free PMC Article
    3. Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication. Yi X, et al. Mol Biol Cell, 2009 Feb. PMID 19056684, Free PMC Article
    4. Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila. Jaklevic B, et al. Genetics, 2006 Dec. PMID 17028317, Free PMC Article
    5. A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate. Chavan A, et al. Genes Dev, 2024 Jun 25. PMID 38866555, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.
      Title: Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.
    2. brwl and stwl likely share a common MADF-BESS ancestor and they are expressed in overlapping spatiotemporal domains to ensure robust development of the female germline.
      Title: Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila.
    3. The identification of stonewall (stwl) as a novel hydroxyurea-hypersensitive mutant, is reported.
      Title: Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.
    4. stwl(UY823) overexpression, like overexpression of the wild-type gene, activated G1/S transition and apoptosis
      Title: The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducers.
    5. Stwl-dependent transcriptional repression does not target bam, but rather Stwl represses the expression of many genes, including those that may be targeted by Nanos and Pumilio translational inhibition.
      Title: Stonewalling Drosophila stem cell differentiation by epigenetic controls.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c14408255-14408198 mobile_element_type = transposon:INE-1{}3249

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stonewall
    Names
    CG3836-PA
    CG3836-PB
    CG3836-PC
    STONEWALL
    alpha transcript
    stwl-PA
    stwl-PB
    stwl-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14402930..14409939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274910.1 → NP_001261839.1  stonewall, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261839.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24156, Q9VUE5
      Conserved Domains (2) summary
      smart00595
      Location:11 → 98
      MADF; subfamily of SANT domain
      pfam02944
      Location:604 → 637
      BESS; BESS motif

    2. NM_079344.3 → NP_524068.2  stonewall, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524068.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24156, Q9VUE5
      Related
      FBpp0075471
      Conserved Domains (2) summary
      smart00595
      Location:11 → 98
      MADF; subfamily of SANT domain
      pfam02944
      Location:604 → 637
      BESS; BESS motif

    3. NM_001274909.1 → NP_001261838.1  stonewall, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A075BJG7, A0A075BLW2, M9PI58
      Conserved Domains (3) summary
      pfam02944
      Location:566 → 599
      BESS; BESS motif
      cl01319
      Location:132 → 203
      HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
      cl23759
      Location:13 → 60
      GT1; GT1, myb-like, SANT family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI58 M9PI58
    Q24156 Q24156
    Q9VUE5 Q9VUE5

    Gene LinkOut

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