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    CCC1 Ccc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCC1
    Official Full Name
    Ccc1p
    Primary source
    SGD:S000004210
    Locus tag
    YLR220W
    See related
    AllianceGenome:SGD:S000004210; FungiDB:YLR220W; VEuPathDB:YLR220W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferrous iron transmembrane transporter activity and manganese ion transmembrane transporter activity. Involved in detoxification of iron ion; intracellular monoatomic cation homeostasis; and transition metal ion transport. Located in Golgi apparatus and fungal-type vacuole membrane. Is active in fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CCC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (576825..577793)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Coa4p Neighboring gene Msc3p Neighboring gene Rsa3p Neighboring gene Utp13p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mössbauer, EPR, and modeling study of iron trafficking and regulation in Δccc1 and CCC1-up Saccharomyces cerevisiae. Cockrell A, et al. Biochemistry, 2014 May 13. PMID 24785783, Free PMC Article
    2. An Internal Promoter Drives the Expression of a Truncated Form of CCC1 Capable of Protecting Yeast from Iron Toxicity. Amaral C, et al. Microorganisms, 2021 Jun 20. PMID 34203091, Free PMC Article
    3. Iron toxicity in yeast: transcriptional regulation of the vacuolar iron importer Ccc1. Li L, et al. Curr Genet, 2018 Apr. PMID 29043483, Free PMC Article
    4. The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions. Lapinskas PJ, et al. Mol Microbiol, 1996 Aug. PMID 8866476
    5. Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron. Sorribes-Dauden R, et al. Genes (Basel), 2021 Jul 23. PMID 34440294, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron.
      Title: Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron.
    2. The identification of multiple independent transcriptional pathways that regulate the levels of Ccc1 under high iron conditions accentuates the importance of protecting cells from the toxic effects of high iron
      Title: Iron toxicity in yeast: transcriptional regulation of the vacuolar iron importer Ccc1.
    3. Data suggest that SNF1 deletion acts synergistically with YAP5 deletion to regulate transcription of vacuolar iron importer CCC1 and to regulate iron resistance; SNF1 deletion with MSN2/MSN4 deletion results in additive effects on CCC1 transcription. (SNF1 = sucrose non-fermenting kinase 1; YAP5 = transcription factor YAP5; CCC1 = Ca(II)-sensitive cross-complementer 1; MSN = stress-responsive transcriptional activator)
      Title: The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of iron ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular manganese ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular manganese ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular sequestering of iron ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manganese ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ccc1p
    NP_013321.1
    • Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to vacuole decreases upon DNA replication stress; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      576825..577793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182107.1 → NP_013321.1  TPA: Ccc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYM0, P47818
      UniProtKB/TrEMBL
      A7A1A7, B3RHA8, C7GIU8, C8ZDI4, G2WJ49, N1NZF3
      Conserved Domains (1) summary
      cd02435
      Location:74 → 295
      CCC1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47818.1

    Gene LinkOut

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