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    az2 az2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    az2provided by FlyBase
    Official Full Name
    az2provided by FlyBase
    Primary source
    FLYBASE:FBgn0025185
    Locus tag
    Dmel_CG1605
    See related
    AllianceGenome:FB:FBgn0025185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1605; Dmel\CG1605; zf43C
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in nurse cell; oocyte; organism; and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See az2 in Genome Data Viewer
    Location:
    43D1-43D1; 2-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7510622..7512749, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3398127..3400254, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene disc proliferation abnormal Neighboring gene dilute class unconventional myosin Neighboring gene mitochondrial translation elongation factor Tu 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of az2, a putative zinc finger transcription factor from Drosophila melanogaster. McCormack A, et al. Dev Genes Evol, 1998 May. PMID 9601993
    2. Identification of an essential gene encoding a class-V unconventional myosin in Drosophila melanogaster. MacIver B, et al. Eur J Biochem, 1998 Nov 1. PMID 9839940
    3. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
    4. Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans. Zhao L, et al. PLoS Genet, 2015 May. PMID 25950438, Free PMC Article
    5. RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs. Seinen E, et al. PLoS One, 2010 Oct 1. PMID 20957038, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    az2
    Names
    CG1605-PA
    az2-PA
    zinc finger protein 43C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7510622..7512749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136445.3 → NP_610289.2  az2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610289.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z702, Q5BIC3, Q95TI1
      Related
      FBpp0088053
      Conserved Domains (3) summary
      sd00017
      Location:467 → 488
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam10545
      Location:157 → 242
      MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like
      cl23759
      Location:276 → 341
      GT1; GT1, myb-like, SANT family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44421 O44421
    Q5BIC3 Q5BIC3
    Q95TI1 Q95TI1

    Gene LinkOut

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