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    CG4752 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4752provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034733
    Locus tag
    Dmel_CG4752
    See related
    AllianceGenome:FB:FBgn0034733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4752
    Summary
    Predicted to enable 5-oxoprolinase (ATP-hydrolyzing) activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval dorsal vessel; epithelium; gastric caecum; and gut section. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4752 in Genome Data Viewer
    Location:
    58E3-58E3; 2-100 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22478379..22483054)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18365884..18370559)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1. Zhang T, et al. J Cell Sci, 2015 Aug 1. PMID 26092939, Free PMC Article
    2. Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila. Sebastian B, et al. J Circadian Rhythms, 2022. PMID 36561348, Free PMC Article
    3. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article
    4. A gene-specific T2A-GAL4 library for Drosophila. Lee PT, et al. Elife, 2018 Mar 22. PMID 29565247, Free PMC Article
    5. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5-oxoprolinase (ATP-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4752-PA
    NP_611675.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22478379..22483054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137831.3 → NP_611675.2  uncharacterized protein Dmel_CG4752 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611675.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS45, Q9W247
      Related
      FBpp0071743
      Conserved Domains (4) summary
      PLN02666
      Location:5 → 1262
      PLN02666; 5-oxoprolinase
      pfam01968
      Location:233 → 531
      Hydantoinase_A; Hydantoinase/oxoprolinase
      pfam02538
      Location:737 → 1259
      Hydantoinase_B; Hydantoinase B/oxoprolinase
      pfam05378
      Location:8 → 214
      Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS45 Q8MS45
    Q9W247 Q9W247

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