U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    MICU1 Mitochondrial calcium uptake 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33999, updated on 27-Dec-2024

    Summary

    Official Symbol
    MICU1provided by FlyBase
    Official Full Name
    Mitochondrial calcium uptake 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031893
    Locus tag
    Dmel_CG4495
    See related
    AllianceGenome:FB:FBgn0031893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4495; Dmel\CG4495; micu1
    Summary
    Predicted to enable calcium ion binding activity. Involved in anesthesia-resistant memory; calcium import into the mitochondrion; and medium-term memory. Predicted to be part of uniplex complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and head mesoderm. Used to study myopathy with extrapyramidal signs. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MICU1 in Genome Data Viewer
    Location:
    27E4-27E4; 2-25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7182234..7185529)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7182234..7185529)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46210 Neighboring gene long non-coding RNA:CR44613 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    Component Evidence Code Pubs
    part_of uniplex complex  
    part_of uniplex complex  
    part_of uniplex complex PubMed 

    General protein information

    Preferred Names
    mitochondrial calcium uptake 1
    Names
    CG4495-PA
    CG4495-PB
    MICU1-PA
    MICU1-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7182234..7185529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103640.2 → NP_001097110.1  mitochondrial calcium uptake 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEI2, Q9VM38
      Conserved Domains (2) summary
      pfam13833
      Location:438 → 491
      EF-hand_8; EF-hand domain pair
      cl08302
      Location:252 → 293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_135256.3 → NP_609100.1  mitochondrial calcium uptake 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609100.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEI2
      Related
      FBpp0079033
      Conserved Domains (2) summary
      pfam13833
      Location:437 → 490
      EF-hand_8; EF-hand domain pair
      cl08302
      Location:251 → 292
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    External link. Please review our privacy policy.