U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RRS1 ribosome biogenesis regulator 1 homolog [ Homo sapiens (human) ]

    Gene ID: 23212, updated on 9-Dec-2024

    Summary

    Official Symbol
    RRS1provided by HGNC
    Official Full Name
    ribosome biogenesis regulator 1 homologprovided by HGNC
    Primary source
    HGNC:HGNC:17083
    See related
    Ensembl:ENSG00000179041 MIM:618311; AllianceGenome:HGNC:17083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables 5S rRNA binding activity. Involved in several processes, including mitotic metaphase chromosome alignment; protein localization to nucleolus; and ribosomal large subunit assembly. Located in condensed nuclear chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RRS1 in Genome Data Viewer
    Location:
    8q13.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66429014..66430733)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66854584..66856303)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67341249..67342968)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724687 Neighboring gene long intergenic non-protein coding RNA 967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:67140301-67141126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:67141127-67141950 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:67164075-67164914 Neighboring gene MPRA-validated peak7057 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19253 Neighboring gene RRS1 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr8:67358104-67358753 Neighboring gene alcohol dehydrogenase iron containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:67370279-67370807 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) (RRS1) at amino acid residues 222-223 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ribosome biogenesis regulatory protein homolog
    Names
    RRS1 ribosome biogenesis regulator homolog
    homolog of yeast ribosome biogenesis regulator
    homolog of yeast ribosome biogenesis regulatory protein RRS1
    ribosome biogenesis regulator homolog
    ribosome biogenesis regulatory protein RRS1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015169.4NP_055984.1  ribosome biogenesis regulatory protein homolog

      See identical proteins and their annotated locations for NP_055984.1

      Status: VALIDATED

      Source sequence(s)
      AC009879, BC001811, D25218
      Consensus CDS
      CCDS6189.1
      UniProtKB/Swiss-Prot
      Q15050, Q9BUX8
      Related
      ENSP00000322396.2, ENST00000320270.4
      Conserved Domains (1) summary
      pfam04939
      Location:31193
      RRS1; Ribosome biogenesis regulatory protein (RRS1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      66429014..66430733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      66854584..66856303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)