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    RPL7 ribosomal protein L7 [ Homo sapiens (human) ]

    Gene ID: 6129, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPL7provided by HGNC
    Official Full Name
    ribosomal protein L7provided by HGNC
    Primary source
    HGNC:HGNC:10363
    See related
    Ensembl:ENSG00000147604 MIM:604166; AllianceGenome:HGNC:10363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L7; uL30; humL7-1
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 918.2), bone marrow (RPKM 482.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPL7 in Genome Data Viewer
    Location:
    8q21.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73290242..73294466, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (73719762..73723986, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74202477..74206701, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375901 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74152441-74153040 Neighboring gene chromosome 8 open reading frame 89 Neighboring gene peroxiredoxin like 2A pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74197691-74198192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74198193-74198692 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205120-74205828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205829-74206536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74211031-74211531 Neighboring gene NANOG hESC enhancer GRCh37_chr8:74216479-74216980 Neighboring gene retinol dehydrogenase 10 Neighboring gene RDH10 antisense RNA 1 Neighboring gene uncharacterized LOC105375899

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L7 (RPL7) at amino acid residues 3-4 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117326

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein uL30
    Names
    60S ribosomal protein L7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000971.4NP_000962.2  large ribosomal subunit protein uL30 isoform 1

      See identical proteins and their annotated locations for NP_000962.2

      Status: REVIEWED

      Source sequence(s)
      AC111149, BC009599, X52967
      Consensus CDS
      CCDS6212.1
      UniProtKB/Swiss-Prot
      A8K504, P18124, Q15289, Q3KQU0, Q5I0X1, Q6IBM9
      UniProtKB/TrEMBL
      O95036
      Related
      ENSP00000339795.2, ENST00000352983.7
      Conserved Domains (1) summary
      TIGR01310
      Location:16248
      uL30_euk; 60S ribosomal protein uL30, eukaryotic form
    2. NM_001363737.2NP_001350666.1  large ribosomal subunit protein uL30 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC111149
      Consensus CDS
      CCDS87615.1
      UniProtKB/TrEMBL
      A8MUD9, O95036
      Related
      ENSP00000379729.1, ENST00000396465.5
      Conserved Domains (1) summary
      TIGR01310
      Location:3208
      uL30_euk; 60S ribosomal protein uL30, eukaryotic form

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      73290242..73294466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      73719762..73723986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)