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    ADAM10 ADAM metallopeptidase domain 10 [ Homo sapiens (human) ]

    Gene ID: 102, updated on 9-Dec-2024

    Summary

    Official Symbol
    ADAM10provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 10provided by HGNC
    Primary source
    HGNC:HGNC:188
    See related
    Ensembl:ENSG00000137845 MIM:602192; AllianceGenome:HGNC:188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717
    Summary
    Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 30.9), thyroid (RPKM 26.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAM10 in Genome Data Viewer
    Location:
    15q21.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (58588809..58749707, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (56390788..56551686, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (58881008..59041906, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:58540501-58541001 Neighboring gene Sharpr-MPRA regulatory region 5540 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:58576109-58577308 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:58624073-58625272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:58638163-58638664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:58638665-58639164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:58655345-58655845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9469 Neighboring gene MPRA-validated peak2354 silencer Neighboring gene Sharpr-MPRA regulatory region 6038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9470 Neighboring gene Sharpr-MPRA regulatory region 12189 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:58731214-58731454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:58741275-58741775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6480 Neighboring gene LIPC antisense RNA 1 Neighboring gene lipase C, hepatic type Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:58813484-58814683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:58840709-58841347 Neighboring gene NANOG hESC enhancer GRCh37_chr15:58853387-58853916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9475 Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:58978446-58978628 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene high mobility group box 1 pseudogene 51 Neighboring gene heat shock protein 90 alpha family class B member 4, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9476 Neighboring gene RN7SK pseudogene 95 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:59041039-59041674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9478 Neighboring gene ATP synthase membrane subunit g pseudogene Neighboring gene small nucleolar RNA, C/D box 3 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated ADAM10, ADAM17, and TNF when compared to healthy donors PubMed
    Knockdown of ADAM metallopeptidase domain 10 (ADAM10) by siRNA inhibits HIV-1 replication in CD4+ T lymphocytes PubMed
    Knockdown of ADAM metallopeptidase domain 10 (ADAM10) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ADAM10; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
    Nef nef HIV-1 Nef associates with ADAM10 in extracellular vesicles isolated from HIV-1-infected patients PubMed
    Pr55(Gag) gag Treatment of PBMCs taken from treatment-naive HIV chronically infected individuals with a HIV-1 Gag peptide pool in the presence of ADAM10 inhibitor upregulates the levels of Tim-3 and IFN-gamma in CD8+ T cells PubMed
    integrase gag-pol HIV-1 IN co-localizes and co-immunoprecipitates with ADAM10 in U373 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables integrin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metalloendopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid precursor protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in constitutive protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epidermal growth factor receptor ligand maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein catabolic process at postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of pore complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in tetraspanin-enriched microdomain IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    a disintegrin and metalloprotease domain 10
    kuzbanian protein homolog
    mammalian disintegrin-metalloprotease
    NP_001101.1
    NP_001307499.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033876.2 RefSeqGene

      Range
      5001..165899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110.4NP_001101.1  disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001101.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA243020, AC018904, AF009615, AY726599, BE327886, BX372217, DA941750
      Consensus CDS
      CCDS10167.1
      UniProtKB/Swiss-Prot
      B4DU28, O14672, Q10742, Q92650
      Related
      ENSP00000260408.3, ENST00000260408.8
      Conserved Domains (3) summary
      smart00050
      Location:466545
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220459
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:46156
      Pep_M12B_propep; Reprolysin family propeptide
    2. NM_001320570.2NP_001307499.1  disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AC018904, AC091046
      Conserved Domains (3) summary
      smart00050
      Location:435514
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220428
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:43156
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      58588809..58749707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      56390788..56551686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)