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    proW glycine betaine ABC transporter membrane subunit ProW [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947145, updated on 3-Dec-2024

    Summary

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    Official Symbol
    proW
    Official Full Name
    glycine betaine ABC transporter membrane subunit ProW
    Primary source
    ECOCYC:EG10772
    Locus tag
    b2678
    See related
    ASAP:ABE-0008816
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2672; osrA; proU
    Summary
    ProVWX, the high-affinity transport system for the osmoprotectant glycine betaine, is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10772].
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    Genomic context

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    Sequence:
    NC_000913.3 (2806010..2807074)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI Neighboring gene ribonucleoside-diphosphate reductase 2 subunit alpha Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter periplasmic binding protein ProX Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of phoA and lacZ fusions to study the membrane topology of ProW, a component of the osmoregulated ProU transport system of Escherichia coli. Haardt M, et al. J Bacteriol, 1996 Sep. PMID 8808924, Free PMC Article
    2. Osmotic control of proU transcription is mediated through direct action of potassium glutamate on the transcription complex. Prince WS, et al. J Biol Chem, 1990 Oct 15. PMID 1976630
    3. Osmoregulation in Escherichia coli: complementation analysis and gene-protein relationships in the proU locus. Dattananda CS, et al. J Bacteriol, 1989 Apr. PMID 2649478, Free PMC Article
    4. Cloned structural genes for the osmotically regulated binding-protein-dependent glycine betaine transport system (ProU) of Escherichia coli K-12. Faatz E, et al. Mol Microbiol, 1988 Mar. PMID 2837616
    5. Molecular cloning of an osmoregulatory locus in Escherichia coli: increased proU gene dosage results in enhanced osmotolerance. Gowrishankar J, et al. J Bacteriol, 1986 Dec. PMID 3536868, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables amine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carnitine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carnitine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in choline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine betaine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycine betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycine betaine transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of ProVWX complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine betaine ABC transporter membrane subunit ProW
    NP_417164.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2806010..2807074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417164.1 glycine betaine ABC transporter membrane subunit ProW [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417164.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A797HWJ6
      Conserved Domains (1) summary
      PRK10952
      Location:1 → 354
      PRK10952; proline/glycine betaine ABC transporter permease ProW
    Nucleotide Protein
    Heading Accession and Version

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