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    higB ribosome-dependent mRNA interferase toxin HigB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947591, updated on 3-Dec-2024

    Summary

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    Official Symbol
    higB
    Official Full Name
    ribosome-dependent mRNA interferase toxin HigB
    Primary source
    ECOCYC:G7602
    Locus tag
    b3083
    See related
    ASAP:ABE-0010128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3073; ygjN
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    Genomic context

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    Sequence:
    NC_000913.3 (3234141..3234455, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycoside hydrolase Neighboring gene 2,4-dienoyl-CoA reductase Neighboring gene antitoxin/DNA-binding transcriptional repressor HigA Neighboring gene 23S rRNA m(2)G1835 methyltransferase Neighboring gene putative metal-dependent hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. Xu BS, et al. Biochem Biophys Res Commun, 2019 Jun 18. PMID 31014676
    2. Structural insight into the E. coli HigBA complex. Yang J, et al. Biochem Biophys Res Commun, 2016 Sep 30. PMID 27601326
    3. Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Christensen-Dalsgaard M, et al. Mol Microbiol, 2010 Jan. PMID 19943910, Free PMC Article
    4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
    5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of toxin-antitoxin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome-dependent mRNA interferase toxin HigB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3234141..3234455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417554.1 ribosome-dependent mRNA interferase toxin HigB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417554.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DM86
      Conserved Domains (1) summary
      COG4680
      Location:1 → 99
      HigB; mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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