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    CG14995 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14995provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035497
    Locus tag
    Dmel_CG14995
    See related
    AllianceGenome:FB:FBgn0035497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.252; bs17f06.y1; CT34848; Dmel\CG14995; NEST:bs15f01; NEST:bs17f06
    Summary
    Predicted to be involved in cytoskeleton organization. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic ventral epidermis; embryonic/larval midgut primordium; and larval foregut atrium. Human ortholog(s) of this gene implicated in axial spondylometaphyseal dysplasia. Orthologous to human CFAP410 (cilia and flagella associated protein 410). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14995 in Genome Data Viewer
    Location:
    64A5-64A6; 3-10 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4094343..4103256, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4094343..4103256, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Fumarylacetoacetase Neighboring gene Glutamic acid decarboxylase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45670 Neighboring gene Fermitin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article
    2. Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization. Dequéant ML, et al. Proc Natl Acad Sci U S A, 2015 Oct 20. PMID 26438832, Free PMC Article
    3. A SAGE approach to discovery of genes involved in autophagic cell death. Gorski SM, et al. Curr Biol, 2003 Feb 18. PMID 12593804
    4. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
    5. Gene discovery using computational and microarray analysis of transcription in the Drosophila melanogaster testis. Andrews J, et al. Genome Res, 2000 Dec. PMID 11116097, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14995-PA
    CG14995-PC
    CG14995-PD
    CG14995-PF
    CG14995-PG
    CG14995-PH
    CG14995-PI
    gandalf

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4094343..4103256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168059.4 → NP_728935.1  uncharacterized protein Dmel_CG14995, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZI4
      Related
      FBpp0073127
      Conserved Domains (4) summary
      cd00116
      Location:56 → 123
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:21 → 42
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:44 → 82
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:41 → 99
      LRR_8; Leucine rich repeat

    2. NM_168058.3 → NP_728934.1  uncharacterized protein Dmel_CG14995, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728934.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0Q7
      Related
      FBpp0073128
      Conserved Domains (4) summary
      cd00116
      Location:56 → 123
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:21 → 42
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:44 → 82
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:41 → 99
      LRR_8; Leucine rich repeat

    3. NM_001274468.1 → NP_001261397.1  uncharacterized protein Dmel_CG14995, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAM2
      Conserved Domains (4) summary
      cd00116
      Location:56 → 123
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:21 → 42
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:44 → 82
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:41 → 99
      LRR_8; Leucine rich repeat

    4. NM_001169871.1 → NP_001163342.1  uncharacterized protein Dmel_CG14995, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2VEF8, E1JIC6
      Conserved Domains (3) summary
      sd00031
      Location:44 → 64
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:44 → 82
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:41 → 99
      LRR_8; Leucine rich repeat

    5. NM_168057.4 → NP_728933.1  uncharacterized protein Dmel_CG14995, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVI4, Q8IRC2
      Related
      FBpp0073129
      Conserved Domains (3) summary
      sd00031
      Location:21 → 42
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:44 → 82
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:41 → 99
      LRR_8; Leucine rich repeat

    6. NM_139600.4 → NP_647857.3  uncharacterized protein Dmel_CG14995, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647857.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV59, Q95U18
      Conserved Domains (3) summary
      sd00031
      Location:79 → 99
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:79 → 117
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:76 → 134
      LRR_8; Leucine rich repeat

    7. NM_001169872.2 → NP_001163343.1  uncharacterized protein Dmel_CG14995, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163343.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVI4, E1JIC5
      Conserved Domains (3) summary
      sd00031
      Location:21 → 42
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:44 → 82
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:41 → 99
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIC5 E1JIC5
    E1JIC6 E1JIC6
    F0JAM2 F0JAM2
    Q8I0Q7 Q8I0Q7
    Q8IRC2 Q8IRC2
    Q95U18 Q95U18
    Q9VZI4 Q9VZI4

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