Gnmt Glycine N-methyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gnmtprovided by FlyBase
Official Full Name: Glycine N-methyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0038074
Locus tag: Dmel_CG6188
See related: AllianceGenome:FB:FBgn0038074
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6188; Dmel\CG6188; gnmt
Summary: Predicted to enable cation binding activity; glycine N-methyltransferase activity; and identical protein binding activity. Involved in several processes, including S-adenosylmethionine catabolic process; determination of adult lifespan; and sarcosine biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head; embryonic/larval fat body; and gonad. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12674608..12676084)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8500330..8501806)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Regulation of SAM levels by Gnmt is a key component of lifespan extension.
Title: Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in S-adenosylhomocysteine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in S-adenosylmethionine cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in S-adenosylmethionine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homotetramerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcosine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_650223.1

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