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    U4-U6-60K U4-U6 small nuclear riboprotein factor 60K [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    U4-U6-60Kprovided by FlyBase
    Official Full Name
    U4-U6 small nuclear riboprotein factor 60Kprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036733
    Locus tag
    Dmel_CG6322
    See related
    AllianceGenome:FB:FBgn0036733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6322; Dmel\CG6322; Prp4; U4/U6-60K
    Summary
    Enables U4 snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See U4-U6-60K in Genome Data Viewer
    Location:
    74D2-74D2; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17511855..17513912, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17504955..17507012, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene quijote Neighboring gene Organic anion transporting polypeptide 74D Neighboring gene elevated during infection Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Enhancer of decapping 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. Tycowski KT, et al. Mol Cell, 2009 Apr 10. PMID 19285445, Free PMC Article
    2. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
    3. Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages. Ko BS, et al. Exp Mol Med, 2024 Feb. PMID 38374207, Free PMC Article
    4. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Liang D, et al. Mol Cell, 2017 Dec 7. PMID 29174924, Free PMC Article
    5. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables U4 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U4 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U6 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U4-U6 small nuclear riboprotein factor 60K
    Names
    CG6322-PA
    U4-U6-60K-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17511855..17513912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140733.3 → NP_648990.1  U4-U6 small nuclear riboprotein factor 60K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVI0
      Related
      FBpp0074971
      Conserved Domains (4) summary
      smart00500
      Location:132 → 166
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      COG2319
      Location:286 → 553
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:286 → 550
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:357 → 393
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVI0 Q9VVI0

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