CLB6 B-type cyclin CLB6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CLB6
Official Full Name: B-type cyclin CLB6
Primary source: SGD:S000003341
Locus tag: YGR109C
See related: AllianceGenome:SGD:S000003341; FungiDB:YGR109C; VEuPathDB:YGR109C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of DNA replication; and premeiotic DNA replication. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Orthologous to human CCNB3 (cyclin B3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CLB6 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (705359..706501, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of CLB6 expression by the cytoplasmic deadenylase Ccr4 through its coding and 3' UTR regions.
Title: Regulation of CLB6 expression by the cytoplasmic deadenylase Ccr4 through its coding and 3' UTR regions.
Rnr2-Rnr4 redistribution in S phase is triggered by Clb6-Cdc28-mediated phosphorylation of Rnr2, which disrupts the Rnr2-Wtm1 interaction and promotes the release of Rnr2-Rnr4 from the nucleus.
Title: Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase.
Our observations suggest that both APC(Cdh1) and SCF(Cdc4)-dependent proteolysis of Clb6 at the G1/S border are crucial for multiple cell cycle regulated events including proper expression of Clb2, the G1/S and G2/M cell cycle transitions and for proper completion of cell division at mitotic exit.
Title: The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.
These data indicate that Clb5 and Clb6 promote cohesion which is then protected by Pds1 and that both mechanisms are required during replication stress.
Title: S-phase cyclin-dependent kinases promote sister chromatid cohesion in budding yeast.
the presence of Clb6, which is eliminated early in an unperturbed S phase, is stabilized when replication is compromised by replication stress or DNA damage
Title: Cyclin regulation by the s phase checkpoint.
Data show that, at early S phase, Hog1 prevents firing of replication origins by delaying the accumulation of the S phase cyclins Clb5 and Clb6.
Title: The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.
The S-phase cyclin Clb6 can promote initiation of DNA replication without blocking reinitiation, and this activity is highly toxic when the ability of other cyclins to block reinitiation are prevented by mutation.
Title: Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition.
SCF(Cdc4) ubiquitin ligase complex regulates Clb6 turnover
Title: Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3042 (e-PCR)
- UniSTS:515631

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in premeiotic DNA replication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in premeiotic DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in traversing start control point of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: B-type cyclin CLB6

NP_011623.3

B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

705359..706501 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181238.3 → NP_011623.3 TPA: B-type cyclin CLB6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011623.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUP0, P32943

UniProtKB/TrEMBL

A6ZUC4, B3LIB8, B5VJ54, C7GQ81, C8Z901, G2WEJ3, N1P3N6

Conserved Domains (1) summary

COG5024
Location:1 → 380

COG5024; Cyclin [Cell division and chromosome partitioning]