U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pam peptidylglycine alpha-amidating monooxygenase [ Mus musculus (house mouse) ]

    Gene ID: 18484, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pamprovided by MGI
    Official Full Name
    peptidylglycine alpha-amidating monooxygenaseprovided by MGI
    Primary source
    MGI:MGI:97475
    See related
    Ensembl:ENSMUSG00000026335 AllianceGenome:MGI:97475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PHM
    Summary
    Predicted to enable several functions, including metal ion binding activity; peptidylamidoglycolate lyase activity; and peptidylglycine monooxygenase activity. Predicted to be involved in several processes, including fatty acid primary amide biosynthetic process; peptide amidation; and response to zinc ion. Predicted to be located in several cellular components, including perikaryon; secretory granule membrane; and trans-Golgi network. Predicted to be active in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; forelimb bud; limb interdigital region; and sensory organ. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 108.5), adrenal adult (RPKM 50.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pam in Genome Data Viewer
    Location:
    1 D; 1 47.76 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (97748816..98023578, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (97821091..98095853, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3293 Neighboring gene macrophage immunometabolism regulator Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene STARR-seq mESC enhancer starr_01779 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:99666627-99666810 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene STARR-seq mESC enhancer starr_01781 Neighboring gene predicted gene, 31771 Neighboring gene basic transcription factor 3, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_01782 Neighboring gene RIKEN cDNA B230216N24 gene Neighboring gene STARR-seq mESC enhancer starr_01784 Neighboring gene STARR-seq mESC enhancer starr_01785 Neighboring gene predicted gene, 24465 Neighboring gene predicted gene, 51640 Neighboring gene RIKEN cDNA 1810006J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E3294 Neighboring gene STARR-seq mESC enhancer starr_01786 Neighboring gene predicted gene 29461

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidylamidoglycolate lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidylamidoglycolate lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidylglycine monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidylglycine monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidylglycine monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidylglycine monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid primary amide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid primary amide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide amidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide amidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptide metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    peptidyl-glycine alpha-amidating monooxygenase
    Names
    PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PRECURSOR (PAM)
    NP_001344056.1
    NP_001407914.1
    NP_001407915.1
    NP_001407916.1
    NP_001407917.1
    NP_001407918.1
    NP_001407919.1
    NP_001407920.1
    NP_001407921.1
    NP_038654.2
    XP_006529306.1
    XP_011246239.1
    XP_011246240.1
    XP_011246241.1
    XP_017174771.1
    XP_017174773.1
    XP_017174775.1
    XP_030108022.1
    XP_030108025.1
    XP_030108027.1
    XP_030108037.1
    XP_030108045.1
    XP_030108046.1
    XP_030108047.1
    XP_030108050.1
    XP_036018665.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357127.2NP_001344056.1  peptidyl-glycine alpha-amidating monooxygenase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
      Consensus CDS
      CCDS87863.1
      UniProtKB/Swiss-Prot
      E9QL07, P97467
      Related
      ENSMUSP00000057112.9, ENSMUST00000058762.15
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    2. NM_001420985.1NP_001407914.1  peptidyl-glycine alpha-amidating monooxygenase isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
    3. NM_001420986.1NP_001407915.1  peptidyl-glycine alpha-amidating monooxygenase isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
      UniProtKB/TrEMBL
      E9Q704
      Related
      ENSMUSP00000125418.2, ENSMUST00000161567.8
    4. NM_001420987.1NP_001407916.1  peptidyl-glycine alpha-amidating monooxygenase isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
    5. NM_001420988.1NP_001407917.1  peptidyl-glycine alpha-amidating monooxygenase isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
    6. NM_001420989.1NP_001407918.1  peptidyl-glycine alpha-amidating monooxygenase isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
    7. NM_001420990.1NP_001407919.1  peptidyl-glycine alpha-amidating monooxygenase isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
    8. NM_001420991.1NP_001407920.1  peptidyl-glycine alpha-amidating monooxygenase isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
    9. NM_001420992.1NP_001407921.1  peptidyl-glycine alpha-amidating monooxygenase isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
      UniProtKB/TrEMBL
      F8VQA4
    10. NM_013626.4NP_038654.2  peptidyl-glycine alpha-amidating monooxygenase isoform 1 precursor

      See identical proteins and their annotated locations for NP_038654.2

      Status: VALIDATED

      Source sequence(s)
      AC102191, AC157923
      Consensus CDS
      CCDS48331.1
      UniProtKB/TrEMBL
      F8VQA4
      Related
      ENSMUSP00000095228.4, ENSMUST00000097625.10
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:62172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      97748816..98023578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252190.1XP_030108050.1  peptidyl-glycine alpha-amidating monooxygenase isoform X13

      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    2. XM_030252187.1XP_030108047.1  peptidyl-glycine alpha-amidating monooxygenase isoform X12

      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    3. XM_030252186.1XP_030108046.1  peptidyl-glycine alpha-amidating monooxygenase isoform X11

      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    4. XM_030252185.1XP_030108045.1  peptidyl-glycine alpha-amidating monooxygenase isoform X10

      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    5. XM_006529243.4XP_006529306.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    6. XM_036162772.1XP_036018665.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    7. XM_030252162.2XP_030108022.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    8. XM_030252165.2XP_030108025.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    9. XM_011247939.4XP_011246241.1  peptidyl-glycine alpha-amidating monooxygenase isoform X7

      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    10. XM_017319286.3XP_017174775.1  peptidyl-glycine alpha-amidating monooxygenase isoform X5

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    11. XM_011247938.4XP_011246240.1  peptidyl-glycine alpha-amidating monooxygenase isoform X4

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    12. XM_011247937.4XP_011246239.1  peptidyl-glycine alpha-amidating monooxygenase isoform X2

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    13. XM_017319284.3XP_017174773.1  peptidyl-glycine alpha-amidating monooxygenase isoform X3

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    14. XM_030252167.1XP_030108027.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    15. XM_030252177.1XP_030108037.1  peptidyl-glycine alpha-amidating monooxygenase isoform X7

      Conserved Domains (3) summary
      cd14958
      Location:397704
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    16. XM_017319282.2XP_017174771.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:63172
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:200346
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain