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    EIF3H eukaryotic translation initiation factor 3 subunit H [ Homo sapiens (human) ]

    Gene ID: 8667, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EIF3Hprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Hprovided by HGNC
    Primary source
    HGNC:HGNC:3273
    See related
    Ensembl:ENSG00000147677 MIM:603912; AllianceGenome:HGNC:3273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF3S3; eIF3-p40; eIF3-gamma
    Summary
    Enables metal-dependent deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF3H in Genome Data Viewer
    Location:
    8q23.3-q24.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (116642130..116766374, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (117769451..117883944, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117654369..117768062, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:117543437-117543943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:117595153-117596003 Neighboring gene uncharacterized LOC105375712 Neighboring gene Sharpr-MPRA regulatory region 10947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27827 Neighboring gene uncharacterized LOC105375713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:117690347-117691260 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117702562-117703067 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117742295-117742846 Neighboring gene uncharacterized LOC124902006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27831 Neighboring gene uncharacterized LOC112268030 Neighboring gene UTP23 small subunit processome component Neighboring gene RAD21 cohesin complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3. Zhang L, et al. J Biol Chem, 2008 Aug 29. PMID 18544531, Free PMC Article
    2. Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H. Pittman AM, et al. PLoS Genet, 2010 Sep 16. PMID 20862326, Free PMC Article
    3. Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in human hepatocellular carcinoma. Zhu Q, et al. Oncotarget, 2016 Aug 2. PMID 27340783, Free PMC Article
    4. The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis. Tang J, et al. Cell Commun Signal, 2023 Aug 9. PMID 37559097, Free PMC Article
    5. Overexpression of EIF3S3 promotes cancer cell growth. Savinainen KJ, et al. Prostate, 2006 Aug 1. PMID 16652384

    See all (182) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
      Title: The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
    2. Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer.
      Title: Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer.
    3. The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis.
      Title: The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis.
    4. EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/beta-catenin signaling.
      Title: EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/β-catenin signaling.
    5. The effect of miR-496 on eIF3h in lung invasive adenocarcinoma.
      Title: The effect of miR-496 on eIF3h in lung invasive adenocarcinoma.
    6. EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle.
      Title: EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle.
    7. EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
      Title: EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
    8. EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.
      Title: EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.
    9. METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes and oncogenic transformation; findings uncover a mechanism of translation control that is based on mRNA looping and identify METTL3-eIF3h as a potential therapeutic target for patients with cancer
      Title: mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
    10. EIF3H knockdown inhibited cell proliferation and colony formation in gastric cancer lines and led to cell cycle arrest at the G0/G1 phase, while inducing apoptosis via up- and downregulation of pro- and anti-apoptotic factors, respectively. These results indicate that EIF3H can serve as a novel therapeutic target for the clinical treatment of gastric cancer.
      Title: Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
    EBI GWAS Catalog
    A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
    EBI GWAS Catalog
    Genetic variants near PDGFRA are associated with corneal curvature in Australians.
    EBI GWAS Catalog
    Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
    EBI GWAS Catalog
    Meta-analysis of new genome-wide association studies of colorectal cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of eukaryotic translation initiation factor 3, subunit H (EIF3H) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102958

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal-dependent deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit H
    Names
    eIF-3-gamma
    eIF3 p40 subunit
    eukaryotic translation initiation factor 3 subunit 3
    eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
    eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)
    eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003756.3 → NP_003747.1  eukaryotic translation initiation factor 3 subunit H

      See identical proteins and their annotated locations for NP_003747.1

      Status: VALIDATED

      Source sequence(s)
      AA902770, AC023520, AU117206, U54559
      Consensus CDS
      CCDS6319.1
      UniProtKB/Swiss-Prot
      O15372
      UniProtKB/TrEMBL
      Q53HG0, Q53HR0, Q6IB98
      Related
      ENSP00000429931.1, ENST00000521861.6
      Conserved Domains (1) summary
      cd08065
      Location:37 → 300
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      116642130..116766374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422386.1 → XP_047278342.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    2. XM_047422384.1 → XP_047278340.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    3. XM_047422385.1 → XP_047278341.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    4. XM_047422383.1 → XP_047278339.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    5. XM_047422380.1 → XP_047278336.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    6. XM_047422382.1 → XP_047278338.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    7. XM_047422381.1 → XP_047278337.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      117769451..117883944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15372.1 GenPept UniProtKB/Swiss-Prot:O15372

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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