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    MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 23542, updated on 10-Dec-2024

    Summary

    Official Symbol
    MAPK8IP2provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 8 interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:6883
    See related
    Ensembl:ENSG00000008735 MIM:607755; AllianceGenome:HGNC:6883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IB2; IB-2; JIP2; PRKM8IPL
    Summary
    This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
    Expression
    Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAPK8IP2 in Genome Data Viewer
    Location:
    22q13.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50600793..50613978)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (51111308..51124536)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51039222..51052406)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene CHKB-CPT1B readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14002 Neighboring gene choline kinase beta Neighboring gene CHKB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51039601-51040101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51047655-51048439 Neighboring gene Sharpr-MPRA regulatory region 5053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:51064758-51065540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14004 Neighboring gene arylsulfatase A Neighboring gene uncharacterized LOC124905149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51073690-51074206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51074207-51074721

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ37123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables JUN kinase binding  
    enables MAP-kinase scaffold activity  
    enables MAP-kinase scaffold activity PubMed 
    enables MAP-kinase scaffold activity PubMed 
    enables amyloid-beta binding PubMed 
    enables kinesin binding  
    enables protein binding PubMed 
    enables protein kinase activator activity PubMed 
    enables protein kinase activator activity PubMed 
    enables protein kinase binding PubMed 
    enables protein-containing complex binding  
    enables structural molecule activity PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade  
    acts_upstream_of_or_within MAPK cascade PubMed 
    involved_in behavioral fear response  
    involved_in dendrite morphogenesis  
    involved_in excitatory postsynaptic potential  
    involved_in mating behavior  
    involved_in negative regulation of apoptotic signaling pathway PubMed 
    involved_in nonassociative learning  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in regulation of AMPA receptor activity  
    involved_in regulation of JNK cascade PubMed 
    involved_in regulation of NMDA receptor activity  
    involved_in regulation of signaling receptor activity  
    involved_in regulation of synaptic transmission, glutamatergic  
    involved_in signal complex assembly PubMed 
    involved_in social behavior  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in neuronal cell body  
    located_in postsynaptic density  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    C-Jun-amino-terminal kinase-interacting protein 2
    Names
    JNK MAP kinase scaffold protein 2
    JNK MAP kinase scaffold protein JIP2
    JNK-interacting protein 2
    homologous to mouse JIP-1
    islet-brain 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032955.2 RefSeqGene

      Range
      5109..18294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_012324.6 → NP_036456.1  C-Jun-amino-terminal kinase-interacting protein 2

      See identical proteins and their annotated locations for NP_036456.1

      Status: REVIEWED

      Source sequence(s)
      AF136382, AI066766, AK094442, U62317
      Consensus CDS
      CCDS74886.1
      UniProtKB/Swiss-Prot
      Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4
      UniProtKB/TrEMBL
      Q86VW5
      Related
      ENSP00000330572.4, ENST00000329492.6
      Conserved Domains (2) summary
      cd11942
      Location:608 → 662
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:679 → 824
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50600793..50613978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530679.3 → XP_011528981.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      Q86VW5
      Conserved Domains (2) summary
      cd11942
      Location:609 → 663
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:680 → 825
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
    2. XM_011530680.3 → XP_011528982.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      Q86VW5
      Conserved Domains (2) summary
      cd11942
      Location:571 → 625
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:642 → 787
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
    3. XM_011530681.3 → XP_011528983.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      Q86VW5
      Conserved Domains (2) summary
      cd11942
      Location:564 → 618
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:635 → 780
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      51111308..51124536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325363.1 → XP_054181338.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      Q86VW5
    2. XM_054325364.1 → XP_054181339.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      Q86VW5
    3. XM_054325365.1 → XP_054181340.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      Q86VW5

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