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    RBD2 putative rhomboid protease RBD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RBD2
    Official Full Name
    putative rhomboid protease RBD2
    Primary source
    SGD:S000006167
    Locus tag
    YPL246C
    See related
    AllianceGenome:SGD:S000006167; FungiDB:YPL246C; VEuPathDB:YPL246C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in nuclear periphery. Orthologous to human RHBDD2 (rhomboid domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RBD2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (84509..85297, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene galactose-responsive transcription factor GAL4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene UDP-galactose transporter HUT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Linker 2 of the eukaryotic pre-ribosomal processing factor Mrd1p is an essential interdomain functionally coupled to upstream RNA Binding Domain 2 (RBD2). Lackmann F, et al. PLoS One, 2017. PMID 28388671, Free PMC Article
    2. Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2. Cortesio CL, et al. Mol Biol Cell, 2015 Apr 15. PMID 25694450, Free PMC Article
    3. Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. McQuibban GA, et al. Nature, 2003 May 29. PMID 12774122
    4. Regulation of mitochondrial morphology through proteolytic cleavage of OPA1. Ishihara N, et al. EMBO J, 2006 Jul 12. PMID 16778770, Free PMC Article
    5. Multi-omic Mitoprotease Profiling Defines a Role for Oct1p in Coenzyme Q Production. Veling MT, et al. Mol Cell, 2017 Dec 7. PMID 29220658, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. conclude that Linker 2 has an essential role for Mrd1p beyond just providing a defined length between RBD2 and RBD3
      Title: Linker 2 of the eukaryotic pre-ribosomal processing factor Mrd1p is an essential interdomain functionally coupled to upstream RNA Binding Domain 2 (RBD2).
    2. Through its cytoplasmic tail, Rbd2 regulates the timing of actin assembly at clathrin-mediated endocytic sites by modulating PtdIns(4,5)P2 and myosin recruitment to endocytic sites.
      Title: Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative rhomboid protease RBD2
    NP_015078.1
    • Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      84509..85297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184060.1 → NP_015078.1  TPA: putative rhomboid protease RBD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3C5, Q12270
      UniProtKB/TrEMBL
      A6ZW10, B3LKI6, B5VST8, C7GTQ3, C8ZID3, G2WNU0, N1NW95
      Conserved Domains (1) summary
      pfam01694
      Location:47 → 195
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12270.1

    Gene LinkOut

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