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    Lpcat4 lysophosphatidylcholine acyltransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 99010, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lpcat4provided by MGI
    Official Full Name
    lysophosphatidylcholine acyltransferase 4provided by MGI
    Primary source
    MGI:MGI:2138993
    See related
    Ensembl:ENSMUSG00000027134 AllianceGenome:MGI:2138993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aytl3; Agpat7; LPEAT2
    Summary
    Enables 1-acylglycerophosphocholine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human LPCAT4 (lysophosphatidylcholine acyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 59.3), cortex adult (RPKM 45.0) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lpcat4 in Genome Data Viewer
    Location:
    2 E3; 2 56.96 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112070186..112077456)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112239841..112247111)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1319, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_05384 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112037072-112037373 Neighboring gene STARR-seq mESC enhancer starr_05385 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene predicted gene, 52523 Neighboring gene NUT midline carcinoma, family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4485 Neighboring gene NOP10 ribonucleoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lysophospholipid acyltransferase LPCAT4
    Names
    -acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
    1-AGP acyltransferase 7
    1-AGPAT 7
    1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
    1-acylglycerophosphocholine O-acyltransferase
    1-acylglycerophosphoserine O-acyltransferase
    1-alkenylglycerophosphoethanolamine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    acyltransferase-like 3
    lysophosphatidylethanolamine acyltransferase 2
    plasmalogen synthase
    NP_997089.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207206.2NP_997089.1  lysophospholipid acyltransferase LPCAT4

      See identical proteins and their annotated locations for NP_997089.1

      Status: VALIDATED

      Source sequence(s)
      AL713853, BC068131
      Consensus CDS
      CCDS16548.1
      UniProtKB/Swiss-Prot
      Q66JP7, Q6NVG1
      Related
      ENSMUSP00000028554.4, ENSMUST00000028554.4
      Conserved Domains (2) summary
      cd07991
      Location:109306
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:109295
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      112070186..112077456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)