stan starry night [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stanprovided by FlyBase
Official Full Name: starry nightprovided by FlyBase
Primary source: FLYBASE:FBgn0024836
Locus tag: Dmel_CG11895
See related: AllianceGenome:FB:FBgn0024836
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2R3; CG11895; CT20776; Dmel\CG11895; Flam; Flamingo; fmi; Fmi; FMI; fmi/stan; SN2-7; Stan; STAN
Summary: Predicted to enable cell adhesion molecule binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; neuron differentiation; and positive regulation of cell projection organization. Located in apical plasma membrane and cell-cell junction. Is expressed in several structures, including embryonic/larval tracheal section; nerve; photoreceptor neurons; synaptic neuropil domain; and synaptic neuropil layer. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1); CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2); and CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 47B4-47B7; 2-63 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10673345..10721138)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (6560850..6608643)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fmi and neuronal activity interact to regulate fine-scale topography.
Title: The atypical cadherin flamingo determines the competence of neurons for activity-dependent fine-scale topography.
The transmembrane proteins Frizzled and Flamingo form a stoichiometric nucleus in the complex, while the relative levels of the other four core proteins can vary independently.we show that robust cell polarization is achieved over a range of complex stoichiometries but is dependent on maintaining appropriate levels of the components Frizzled and Strabismus.
Title: Robust Asymmetric Localization of Planar Polarity Proteins Is Associated with Organization into Signalosome-like Domains of Variable Stoichiometry.
microRNA-9a regulates dendrite growth through cadherin protein Flamingo-G protein Galphaq signaling in Drosophila sensory neurons
Title: Epithelial microRNA-9a regulates dendrite growth through Fmi-Gq signaling in Drosophila sensory neurons.
Fmi and Gogo function downstream of Otd in retina.
Title: Orthodenticle Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Drosophila Retina.
Contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development.
Title: Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.
Study demonstrates that the classical cadherin, N-cadherin, and an atypical cadherin, Flamingo, act redundantly to instruct the targeting choices made by every photoreceptor axon.
Title: A network of cadherin-mediated interactions polarizes growth cones to determine targeting specificity.
We deduce that each cell has a mechanism to estimate and compare the numbers of asymmetric bridges, made between Stan and Stan plus Fz, that link it with its neighbouring cells.
Title: Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
In the SMC3 mutant cells, Fmi appeared to be upregulated by a posttranscriptional mechanism(s), and this elevation of Fmi was at least one cause of the planar cell polarity defect.
Title: Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo.
The planar cell polarity gene prickle interacts with flamingo in regulating sensory axon advance at a key choice point - the transition between the peripheral nervous system and the central nervous system.
Title: The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo.
Espinas (Esn), binds to an intracellular juxtamembrane domain of Flamingo (Fmi), and that this Fmi-Esn interplay elicits repulsion between dendritic branches of Drosophila sensory neurons
Title: The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491273

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transmembrane signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in R3/R4 development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in morphogenesis of a polarized epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: starry night

Names: CG11895-PA; CG11895-PB; CG11895-PC; CG11895-PD; CG11895-PE; CG11895-PF; CG11895-PG; flamingo; serpentine cadherin; stan-PA; stan-PB; stan-PC; stan-PD; stan-PE; stan-PF; stan-PG; suppressor of NA9 2-7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

10673345..10721138

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299362.1 → NP_001286291.1 starry night, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286291.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LG27

Conserved Domains (11) summary

cd11304
Location:901 → 1003

Cadherin_repeat; Cadherin tandem repeat domain

smart00180
Location:2095 → 2140

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1483 → 1518

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1558 → 1734

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1760 → 1789

EGF; EGF-like domain

pfam02210
Location:1826 → 1944

Laminin_G_2; Laminin G domain

pfam02793
Location:2144 → 2200

HRM; Hormone receptor domain

pfam16489
Location:2293 → 2458

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02559
Location:2743 → 2802

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:2809 → 3028

7tm_4; Olfactory receptor

cl22855
Location:1963 → 2061

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001259328.2 → NP_001246257.1 starry night, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246257.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH30

Conserved Domains (11) summary

cd11304
Location:901 → 1003

Cadherin_repeat; Cadherin tandem repeat domain

smart00180
Location:2095 → 2140

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1483 → 1518

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1558 → 1734

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1760 → 1789

EGF; EGF-like domain

pfam02210
Location:1826 → 1944

Laminin_G_2; Laminin G domain

pfam02793
Location:2144 → 2200

HRM; Hormone receptor domain

pfam16489
Location:2293 → 2458

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02559
Location:2743 → 2802

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:2809 → 3028

7tm_4; Olfactory receptor

cl22855
Location:1963 → 2061

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001201974.2 → NP_001188903.1 starry night, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188903.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V5N8

UniProtKB/TrEMBL

A0A0B4JD63

Conserved Domains (11) summary

cd11304
Location:901 → 1003

Cadherin_repeat; Cadherin tandem repeat domain

smart00180
Location:2095 → 2140

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1483 → 1518

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1558 → 1734

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1760 → 1789

EGF; EGF-like domain

pfam02210
Location:1826 → 1944

Laminin_G_2; Laminin G domain

pfam02793
Location:2144 → 2200

HRM; Hormone receptor domain

pfam16489
Location:2293 → 2458

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02559
Location:2743 → 2802

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:2809 → 3028

7tm_4; Olfactory receptor

cl22855
Location:1963 → 2061

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001273942.1 → NP_001260871.1 starry night, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260871.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KER2

Conserved Domains (11) summary

cd11304
Location:901 → 1003

Cadherin_repeat; Cadherin tandem repeat domain

smart00180
Location:2095 → 2140

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1483 → 1518

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1558 → 1734

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1760 → 1789

EGF; EGF-like domain

pfam02210
Location:1826 → 1944

Laminin_G_2; Laminin G domain

pfam02793
Location:2144 → 2200

HRM; Hormone receptor domain

pfam16489
Location:2293 → 2458

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02559
Location:2743 → 2802

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:2809 → 3028

7tm_4; Olfactory receptor

cl22855
Location:1963 → 2061

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001259329.2 → NP_001246258.1 starry night, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246258.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6X2

Conserved Domains (11) summary

cd11304
Location:901 → 1003

Cadherin_repeat; Cadherin tandem repeat domain

smart00180
Location:2095 → 2140

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1483 → 1518

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1558 → 1734

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1760 → 1789

EGF; EGF-like domain

pfam02210
Location:1826 → 1944

Laminin_G_2; Laminin G domain

pfam02793
Location:2144 → 2200

HRM; Hormone receptor domain

pfam16489
Location:2293 → 2458

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02559
Location:2743 → 2802

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:2809 → 3028

7tm_4; Olfactory receptor

cl22855
Location:1963 → 2061

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001169642.1 → NP_001163113.1 starry night, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163113.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH30

Conserved Domains (11) summary

cd11304
Location:901 → 1003

Cadherin_repeat; Cadherin tandem repeat domain

smart00180
Location:2095 → 2140

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1483 → 1518

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1558 → 1734

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1760 → 1789

EGF; EGF-like domain

pfam02210
Location:1826 → 1944

Laminin_G_2; Laminin G domain

pfam02793
Location:2144 → 2200

HRM; Hormone receptor domain

pfam16489
Location:2293 → 2458

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02559
Location:2743 → 2802

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:2809 → 3028

7tm_4; Olfactory receptor

cl22855
Location:1963 → 2061

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_165794.4 → NP_724962.3 starry night, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724962.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V5N8

UniProtKB/TrEMBL

A0A0B4JD63

Conserved Domains (11) summary

cd11304
Location:901 → 1003

Cadherin_repeat; Cadherin tandem repeat domain

smart00180
Location:2095 → 2140

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1483 → 1518

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1558 → 1734

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1760 → 1789

EGF; EGF-like domain

pfam02210
Location:1826 → 1944

Laminin_G_2; Laminin G domain

pfam02793
Location:2144 → 2200

HRM; Hormone receptor domain

pfam16489
Location:2293 → 2458

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02559
Location:2743 → 2802

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:2809 → 3028

7tm_4; Olfactory receptor

cl22855
Location:1963 → 2061

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)