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    Fs(2)Ket Female sterile (2) Ketel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35336, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fs(2)Ketprovided by FlyBase
    Official Full Name
    Female sterile (2) Ketelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262743
    Locus tag
    Dmel_CG2637
    See related
    AllianceGenome:FB:FBgn0262743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38E.11; CG2637; dKap-beta; Dmel\CG2637; Fs(2)Hon; fs(2)Ket; Fs(2)ket; Fs(2)Ketel; fs(2)lo-B; fs(2)lto2; fs(2)ltoHD43; Fs(2)Sz6; Fs(2)Sz7; Hon; Imp beta1; imp-beta; impbeta; Impbeta; IMPbeta1; importin beta1; Ket; ketel; Ketel; kettle; Kpnb1; MRE26
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus and regulation of nucleocytoplasmic transport. Located in P granule and nuclear envelope. Is expressed in several structures, including adult brain cell body rind; adult head; female germline cell; gonad; and lamina anlage. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fs(2)Ket in Genome Data Viewer
    Location:
    38E5-38E6; 2-54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20734609..20750941)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20734609..20750941)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Carcinine transporter Neighboring gene Transmembrane 9 superfamily protein member 2 Neighboring gene Alpha-methylacyl-CoA racemase Neighboring gene Nucleostemin 4 Neighboring gene RHAU helicase Neighboring gene diaphanous

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long persistence of importin-beta explains extended survival of cells and zygotes that lack the encoding gene. Villányi Z, et al. Mech Dev, 2008 Mar-Apr. PMID 18221858
    2. P446L-importin-beta inhibits nuclear envelope assembly by sequestering nuclear envelope assembly factors to the microtubules. Tirián L, et al. Eur J Cell Biol, 2003 Jul. PMID 12924630
    3. Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Mann JR, et al. Sci Adv, 2023 Aug 18. PMID 37585529, Free PMC Article
    4. The involvement of Importin-β and peroxiredoxin-6005 in mitochondrial biogenesis. Villanyi Z, et al. Mech Dev, 2011 Mar-Apr. PMID 21272635
    5. Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy. Khalil B, et al. Mol Neurodegener, 2022 Dec 8. PMID 36482422, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nup358 facilitates JH-induced Met nuclear transport in a manner dependent on importin beta and Hsp83.
      Title: Nucleoporin Nup358 facilitates nuclear import of Methoprene-tolerant (Met) in an importin β- and Hsp83-dependent manner.
    2. The regulation of Ketel gene expression depends largely on a DRE motif and action of the DREF, CFDD, CF2-II and BEAF transcription factors.
      Title: The DRE motif is a key component in the expression regulation of the importin-beta encoding Ketel gene in Drosophila.
    3. Data show that the P446L mutant of Drosophila importin beta interferes with nuclear envelope formation during mitosis-to-interphase transition.
      Title: The importin-beta P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chorion-containing eggshell formation HMP PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleocytoplasmic transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    female sterile (2) ketel
    Names
    CG2637-PA
    CG2637-PB
    CG2637-PC
    CG2637-PD
    CG2637-PE
    DImportin-beta
    Fs(2)Ket-PA
    Fs(2)Ket-PB
    Fs(2)Ket-PC
    Fs(2)Ket-PD
    Fs(2)Ket-PE
    Importin-beta
    female sterile(2)lto2
    fs(2) ketel
    hont
    importin beta
    importin beta1
    importinbeta
    ketel
    mRNA-like ncRNA in embryogenesis 26

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20734609..20750941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259180.2 → NP_001246109.1  female sterile (2) ketel, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18388, Q540Y0, Q9V3E6
      UniProtKB/TrEMBL
      M9NDC3
      Conserved Domains (4) summary
      COG5215
      Location:17 → 876
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      pfam03810
      Location:27 → 107
      IBN_N; Importin-beta N-terminal domain
      pfam13513
      Location:386 → 441
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:330 → 360
      HEAT; HEAT repeat [structural motif]

    2. NM_001259179.2 → NP_001246108.1  female sterile (2) ketel, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18388, Q540Y0, Q9V3E6
      UniProtKB/TrEMBL
      M9NDC3
      Conserved Domains (4) summary
      COG5215
      Location:17 → 876
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      pfam03810
      Location:27 → 107
      IBN_N; Importin-beta N-terminal domain
      pfam13513
      Location:386 → 441
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:330 → 360
      HEAT; HEAT repeat [structural motif]

    3. NM_001259181.2 → NP_001246110.1  female sterile (2) ketel, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18388, Q540Y0, Q9V3E6
      UniProtKB/TrEMBL
      M9NDC3
      Conserved Domains (4) summary
      COG5215
      Location:17 → 876
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      pfam03810
      Location:27 → 107
      IBN_N; Importin-beta N-terminal domain
      pfam13513
      Location:386 → 441
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:330 → 360
      HEAT; HEAT repeat [structural motif]

    4. NM_001259182.2 → NP_001246111.1  female sterile (2) ketel, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18388, Q540Y0, Q9V3E6
      UniProtKB/TrEMBL
      M9NDC3
      Conserved Domains (4) summary
      COG5215
      Location:17 → 876
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      pfam03810
      Location:27 → 107
      IBN_N; Importin-beta N-terminal domain
      pfam13513
      Location:386 → 441
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:330 → 360
      HEAT; HEAT repeat [structural motif]

    5. NM_058148.5 → NP_477496.1  female sterile (2) ketel, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477496.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18388, Q540Y0, Q9V3E6
      UniProtKB/TrEMBL
      M9NDC3
      Related
      FBpp0080922
      Conserved Domains (4) summary
      COG5215
      Location:17 → 876
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      pfam03810
      Location:27 → 107
      IBN_N; Importin-beta N-terminal domain
      pfam13513
      Location:386 → 441
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:330 → 360
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDC3 M9NDC3
    O18388.2 O18388

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