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    Ntng1 netrin G1 [ Mus musculus (house mouse) ]

    Gene ID: 80883, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Ntng1provided by MGI
    Official Full Name
    netrin G1provided by MGI
    Primary source
    MGI:MGI:1934028
    See related
    Ensembl:ENSMUSG00000059857 AllianceGenome:MGI:1934028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmnt1; A930010C08Rik
    Summary
    Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including regulation of cell projection organization; regulation of neuron migration; and synaptic membrane adhesion. Acts upstream of or within axonogenesis. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Is expressed in several structures, including brain and enteric nervous system. Orthologous to human NTNG1 (netrin G1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.3), whole brain E14.5 (RPKM 3.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ntng1 in Genome Data Viewer
    Location:
    3 F3; 3 48.47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (109687366..110057291, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (109780050..110149972, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zona pellucida binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109144693-109144846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109164872-109165133 Neighboring gene STARR-positive B cell enhancer mm9_chr3:109251268-109251568 Neighboring gene vav 3 oncogene Neighboring gene STARR-seq mESC enhancer starr_08700 Neighboring gene STARR-seq mESC enhancer starr_08701 Neighboring gene STARR-seq mESC enhancer starr_08702 Neighboring gene STARR-seq mESC enhancer starr_08703 Neighboring gene STARR-seq mESC enhancer starr_08704 Neighboring gene STARR-positive B cell enhancer ABC_E4578 Neighboring gene predicted gene, 25681 Neighboring gene predicted gene, 54214 Neighboring gene STARR-seq mESC enhancer starr_08706 Neighboring gene STARR-positive B cell enhancer mm9_chr3:110053793-110054094 Neighboring gene predicted gene 43405 Neighboring gene protein arginine N-methyltransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs. Meltzer S, et al. Proc Natl Acad Sci U S A, 2022 Oct 25. PMID 36252008, Free PMC Article
    2. Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states. Bolding KA, et al. Elife, 2020 Jul 14. PMID 32662420, Free PMC Article
    3. Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins. Zhang Q, et al. Mol Brain, 2016 Jan 8. PMID 26746425, Free PMC Article
    4. Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits. Zhang Q, et al. Sci Rep, 2016 Jun 27. PMID 27345935, Free PMC Article
    5. Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence. Kelaï S, et al. Addict Biol, 2018 Jan. PMID 28074533

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs.
      Title: A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs.
    2. Decreased Ntng1 expression was initially observed in the nucleus accumbens of mice conditioned to cocaine.
      Title: Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence.
    3. findings support a crucial role for netrin-G1 in dissociable neural circuits for the modulation of emotion-related behaviors, and provide genetic models for investigating the mechanisms underlying the dissociation.
      Title: Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits.
    4. Pre-synaptic netrin-G1 and netrin-G2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties.
      Title: Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.
    5. netrin-G/NGL interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
      Title: Netrin-G/NGL complexes encode functional synaptic diversification.
    6. The complementary expression patterns of Ntng1 and Ntng2 are determined by transcriptional cis-regulatory elements widely scattered in these loci.
      Title: Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.
    7. selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia
      Title: Laminets: laminin- and netrin-related genes expressed in distinct neuronal subsets.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC99878

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cell-cell adhesion mediator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell-cell adhesion mediator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    netrin-G1
    Names
    laminet-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163348.1 → NP_001156820.1  netrin-G1 isoform b

      See identical proteins and their annotated locations for NP_001156820.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) lacks an alternate in-frame exon compared to variant a. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB038666, AB038667, AK034465, BB621591, BC079881
      Consensus CDS
      CCDS59652.1
      UniProtKB/TrEMBL
      F8WJ48
      Related
      ENSMUSP00000120688.3, ENSMUST00000138344.9
      Conserved Domains (3) summary
      smart00180
      Location:364 → 411
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    2. NM_001163349.1 → NP_001156821.1  netrin-G1 isoform c

      See identical proteins and their annotated locations for NP_001156821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) lacks two alternate in-frame exons compared to variant a. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB038665, AB038667, AK034465, BB621591, BC079881
      Consensus CDS
      CCDS59651.1
      UniProtKB/TrEMBL
      F8WJ50
      Related
      ENSMUSP00000117371.3, ENSMUST00000133268.9
      Conserved Domains (3) summary
      cd00054
      Location:373 → 397
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    3. NM_001163350.1 → NP_001156822.1  netrin-G1 isoform d

      See identical proteins and their annotated locations for NP_001156822.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) lacks two alternate in-frame exons and contains two other alternate in-frame exons compared to variant a. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB038664, AB038667, AK034465, BB621591, BC079881
      Consensus CDS
      CCDS59654.1
      UniProtKB/TrEMBL
      F8WJ50
      Related
      ENSMUSP00000116213.3, ENSMUST00000138953.9
      Conserved Domains (3) summary
      cd00054
      Location:415 → 439
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    4. NM_030699.2 → NP_109624.1  netrin-G1 isoform a precursor

      See identical proteins and their annotated locations for NP_109624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB038667, AK034465, BB621591
      Consensus CDS
      CCDS38604.1
      UniProtKB/Swiss-Prot
      Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q8R4G0, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8
      UniProtKB/TrEMBL
      F8WJ48
      Related
      ENSMUSP00000072397.6, ENSMUST00000072596.12
      Conserved Domains (3) summary
      smart00180
      Location:420 → 467
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    5. NM_133488.1 → NP_597995.1  netrin-G1 isoform e precursor

      See identical proteins and their annotated locations for NP_597995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB038663, AB038667, AK034465, BB621591, BC079881
      Consensus CDS
      CCDS59653.1
      UniProtKB/TrEMBL
      F8WJ50
      Related
      ENSMUSP00000119534.3, ENSMUST00000156177.9
      Conserved Domains (3) summary
      cd00054
      Location:395 → 419
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      109687366..110057291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240295.4 → XP_011238597.1  netrin-G1 isoform X5

      UniProtKB/TrEMBL
      F8WJ48
      Related
      ENSMUSP00000118800.3, ENSMUST00000131027.9
      Conserved Domains (2) summary
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    2. XM_011240294.4 → XP_011238596.1  netrin-G1 isoform X4

      UniProtKB/TrEMBL
      F8WJ48
      Conserved Domains (3) summary
      smart00180
      Location:386 → 433
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    3. XM_011240293.4 → XP_011238595.1  netrin-G1 isoform X3

      UniProtKB/TrEMBL
      F8WJ50
      Conserved Domains (3) summary
      smart00180
      Location:406 → 453
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    4. XM_011240292.4 → XP_011238594.1  netrin-G1 isoform X2

      UniProtKB/TrEMBL
      F8WJ50
      Conserved Domains (3) summary
      cd00054
      Location:471 → 495
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    5. XM_011240291.4 → XP_011238593.1  netrin-G1 isoform X1

      See identical proteins and their annotated locations for XP_011238593.1

      UniProtKB/TrEMBL
      F8WJ48
      Conserved Domains (3) summary
      smart00180
      Location:462 → 509
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    6. XM_006502355.5 → XP_006502418.1  netrin-G1 isoform X1

      See identical proteins and their annotated locations for XP_006502418.1

      UniProtKB/TrEMBL
      F8WJ48
      Conserved Domains (3) summary
      smart00180
      Location:462 → 509
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:296 → 342
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00055
      Location:71 → 295
      Laminin_N; Laminin N-terminal (Domain VI)

    RNA

    1. XR_001783784.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001163351.1: Suppressed sequence

      Description
      NM_001163351.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4G0.2 GenPept UniProtKB/Swiss-Prot:Q8R4G0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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